Protective Role of the ACE2/Ang-(1–9) Axis in Cardiovascular Remodeling
Despite reduction in cardiovascular (CV) events and end-organ damage with the current pharmacologic strategies, CV disease remains the primary cause of death in the world. Pharmacological therapies based on the renin angiotensin system (RAS) blockade are used extensively for the treatment of hyperte...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2012/594361 |
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| author | María Paz Ocaranza Jorge E. Jalil |
| author_facet | María Paz Ocaranza Jorge E. Jalil |
| author_sort | María Paz Ocaranza |
| collection | DOAJ |
| description | Despite reduction in cardiovascular (CV) events and end-organ damage with the current pharmacologic strategies, CV disease remains the primary cause of death in the world. Pharmacological therapies based on the renin angiotensin system (RAS) blockade are used extensively for the treatment of hypertension, heart failure, and CV remodeling but in spite of their success the prevalence of end-organ damage and residual risk remain still high. Novel approaches must be discovered for a more effective treatment of residual CV remodeling and risk. The ACE2/Ang-(1–9) axis is a new and important target to counterbalance the vasoconstrictive/proliferative RAS axis. Ang-(1–9) is hydrolyzed slower than Ang-(1–7) and is able to bind the Ang II type 2 receptor. We review here the current experimental evidence suggesting that activation of the ACE2/Ang-(1–9) axis protects the heart and vessels (and possibly the kidney) from adverse cardiovascular remodeling in hypertension as well as in heart failure. |
| format | Article |
| id | doaj-art-0b54ce7dd7c7412aba39d3c6756018a6 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-0b54ce7dd7c7412aba39d3c6756018a62025-02-03T01:11:02ZengWileyInternational Journal of Hypertension2090-03842090-03922012-01-01201210.1155/2012/594361594361Protective Role of the ACE2/Ang-(1–9) Axis in Cardiovascular RemodelingMaría Paz Ocaranza0Jorge E. Jalil1Cardiovascular Diseases Division, School of Medicine, Faculty of Medicine, Pontificia Universidad Catolica de Chile, ChileCardiovascular Diseases Division, School of Medicine, Faculty of Medicine, Pontificia Universidad Catolica de Chile, ChileDespite reduction in cardiovascular (CV) events and end-organ damage with the current pharmacologic strategies, CV disease remains the primary cause of death in the world. Pharmacological therapies based on the renin angiotensin system (RAS) blockade are used extensively for the treatment of hypertension, heart failure, and CV remodeling but in spite of their success the prevalence of end-organ damage and residual risk remain still high. Novel approaches must be discovered for a more effective treatment of residual CV remodeling and risk. The ACE2/Ang-(1–9) axis is a new and important target to counterbalance the vasoconstrictive/proliferative RAS axis. Ang-(1–9) is hydrolyzed slower than Ang-(1–7) and is able to bind the Ang II type 2 receptor. We review here the current experimental evidence suggesting that activation of the ACE2/Ang-(1–9) axis protects the heart and vessels (and possibly the kidney) from adverse cardiovascular remodeling in hypertension as well as in heart failure.http://dx.doi.org/10.1155/2012/594361 |
| spellingShingle | María Paz Ocaranza Jorge E. Jalil Protective Role of the ACE2/Ang-(1–9) Axis in Cardiovascular Remodeling International Journal of Hypertension |
| title | Protective Role of the ACE2/Ang-(1–9) Axis in Cardiovascular Remodeling |
| title_full | Protective Role of the ACE2/Ang-(1–9) Axis in Cardiovascular Remodeling |
| title_fullStr | Protective Role of the ACE2/Ang-(1–9) Axis in Cardiovascular Remodeling |
| title_full_unstemmed | Protective Role of the ACE2/Ang-(1–9) Axis in Cardiovascular Remodeling |
| title_short | Protective Role of the ACE2/Ang-(1–9) Axis in Cardiovascular Remodeling |
| title_sort | protective role of the ace2 ang 1 9 axis in cardiovascular remodeling |
| url | http://dx.doi.org/10.1155/2012/594361 |
| work_keys_str_mv | AT mariapazocaranza protectiveroleoftheace2ang19axisincardiovascularremodeling AT jorgeejalil protectiveroleoftheace2ang19axisincardiovascularremodeling |