Real-Time SPR Biosensing to Detect and Characterize Fast Dissociation Rate Binding Interactions Missed by Endpoint Detection and Implications for Off-Target Toxicity Screening

Real-Time SPR Biosensing to Detect and Characterize Fast Dissociation Rate Binding Interactions Missed by Endpoint Detection and Implications for Off-Target Toxicity Screening

Accurate detection of biomolecular interactions is essential in many areas, from the detection of the presence of biomarkers in the clinic to the development of therapeutic drugs and biologics in biopharma to the understanding of various biological processes in basic research. Traditional endpoint a...

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Bibliographic Details
Main Authors: William Martelly, Rebecca L. Cook, Chidozie Victor Agu, Lydia R. Gushgari, Salvador Moreno, Sailaja Kesiraju, Mukilan Mohan, Bharath Takulapalli
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biomolecules
Subjects:
sensor-integrated proteome on chip
off-target screening
kinetics
SPR biosensing
biomolecular interactions
Online Access:https://www.mdpi.com/2218-273X/15/6/882
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