Hyperibone J exerts antidepressant effects by targeting ADK to inhibit microglial P2X7R/TLR4-mediated neuroinflammation

Hyperibone J exerts antidepressant effects by targeting ADK to inhibit microglial P2X7R/TLR4-mediated neuroinflammation

Introduction: The antidepressant properties of Hypericum species are known. Hyperibone J, a principal component found in the flowers of Hypericum bellum, exhibited in vitro anti-inflammatory effects. However, the antidepressant effects and mechanisms of Hyperibone J remain to be elucidated. Adenosin...

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Bibliographic Details
Main Authors: Ting Li, Yawei Li, Jinhu Chen, Miaomiao Nan, Xin Zhou, Lifang Yang, Wenjun Xu, Chao Zhang, Lingyi Kong
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Advanced Research
Subjects:
Depression
Neuroinflammation
ADK
TLR4
P2X7R
NF-κB
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123224002984
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