Tumor-Derived CXCL1 Promotes Lung Cancer Growth via Recruitment of Tumor-Associated Neutrophils
Neutrophils have a traditional role in inflammatory process and act as the first line of defense against infections. Although their contribution to tumorigenesis and progression is still controversial, accumulating evidence recently has demonstrated that tumor-associated neutrophils (TANs) play a ke...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/6530410 |
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| _version_ | 1832545623287529472 |
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| author | Ming Yuan Ha Zhu Junfang Xu Yuanyuan Zheng Xuetao Cao Qiuyan Liu |
| author_facet | Ming Yuan Ha Zhu Junfang Xu Yuanyuan Zheng Xuetao Cao Qiuyan Liu |
| author_sort | Ming Yuan |
| collection | DOAJ |
| description | Neutrophils have a traditional role in inflammatory process and act as the first line of defense against infections. Although their contribution to tumorigenesis and progression is still controversial, accumulating evidence recently has demonstrated that tumor-associated neutrophils (TANs) play a key role in multiple aspects of cancer biology. Here, we detected that chemokine CXCL1 was dramatically elevated in serum from 3LL tumor-bearing mice. In vitro, 3LL cells constitutively expressed and secreted higher level of CXCL1. Furthermore, knocking down CXCL1 expression in 3LL cells significantly hindered tumor growth by inhibiting recruitment of neutrophils from peripheral blood into tumor tissues. Additionally, tumor-infiltrated neutrophils expressed higher levels of MPO and Fas/FasL, which may be involved in TAN-mediated inhibition of CD4+ and CD8+ T cells. These results demonstrate that tumor-derived CXCL1 contributes to TANs infiltration in lung cancer which promotes tumor growth. |
| format | Article |
| id | doaj-art-0b0f97c774ee4629820b61785c2d494c |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-0b0f97c774ee4629820b61785c2d494c2025-02-03T07:25:14ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/65304106530410Tumor-Derived CXCL1 Promotes Lung Cancer Growth via Recruitment of Tumor-Associated NeutrophilsMing Yuan0Ha Zhu1Junfang Xu2Yuanyuan Zheng3Xuetao Cao4Qiuyan Liu5National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai 200433, ChinaNational Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai 200433, ChinaInstitute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, ChinaNational Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai 200433, ChinaNational Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai 200433, ChinaNational Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai 200433, ChinaNeutrophils have a traditional role in inflammatory process and act as the first line of defense against infections. Although their contribution to tumorigenesis and progression is still controversial, accumulating evidence recently has demonstrated that tumor-associated neutrophils (TANs) play a key role in multiple aspects of cancer biology. Here, we detected that chemokine CXCL1 was dramatically elevated in serum from 3LL tumor-bearing mice. In vitro, 3LL cells constitutively expressed and secreted higher level of CXCL1. Furthermore, knocking down CXCL1 expression in 3LL cells significantly hindered tumor growth by inhibiting recruitment of neutrophils from peripheral blood into tumor tissues. Additionally, tumor-infiltrated neutrophils expressed higher levels of MPO and Fas/FasL, which may be involved in TAN-mediated inhibition of CD4+ and CD8+ T cells. These results demonstrate that tumor-derived CXCL1 contributes to TANs infiltration in lung cancer which promotes tumor growth.http://dx.doi.org/10.1155/2016/6530410 |
| spellingShingle | Ming Yuan Ha Zhu Junfang Xu Yuanyuan Zheng Xuetao Cao Qiuyan Liu Tumor-Derived CXCL1 Promotes Lung Cancer Growth via Recruitment of Tumor-Associated Neutrophils Journal of Immunology Research |
| title | Tumor-Derived CXCL1 Promotes Lung Cancer Growth via Recruitment of Tumor-Associated Neutrophils |
| title_full | Tumor-Derived CXCL1 Promotes Lung Cancer Growth via Recruitment of Tumor-Associated Neutrophils |
| title_fullStr | Tumor-Derived CXCL1 Promotes Lung Cancer Growth via Recruitment of Tumor-Associated Neutrophils |
| title_full_unstemmed | Tumor-Derived CXCL1 Promotes Lung Cancer Growth via Recruitment of Tumor-Associated Neutrophils |
| title_short | Tumor-Derived CXCL1 Promotes Lung Cancer Growth via Recruitment of Tumor-Associated Neutrophils |
| title_sort | tumor derived cxcl1 promotes lung cancer growth via recruitment of tumor associated neutrophils |
| url | http://dx.doi.org/10.1155/2016/6530410 |
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