Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation
Leukocyte extravasation is one of the essential and first steps during the initiation of inflammation. Therefore, a better understanding of the key molecules that regulate this process may help to develop novel therapeutics for treatment of inflammation-based diseases such as atherosclerosis or rheu...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/946509 |
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| _version_ | 1832551021106167808 |
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| author | Michael Schnoor Pilar Alcaide Mathieu-Benoit Voisin Jaap D. van Buul |
| author_facet | Michael Schnoor Pilar Alcaide Mathieu-Benoit Voisin Jaap D. van Buul |
| author_sort | Michael Schnoor |
| collection | DOAJ |
| description | Leukocyte extravasation is one of the essential and first steps during the initiation of inflammation. Therefore, a better understanding of the key molecules that regulate this process may help to develop novel therapeutics for treatment of inflammation-based diseases such as atherosclerosis or rheumatoid arthritis. The endothelial adhesion molecules ICAM-1 and VCAM-1 are known as the central mediators of leukocyte adhesion to and transmigration across the endothelium. Engagement of these molecules by their leukocyte integrin receptors initiates the activation of several signaling pathways within both leukocytes and endothelium. Several of such events have been described to occur during transendothelial migration of all leukocyte subsets, whereas other mechanisms are known only for a single leukocyte subset. Here, we summarize current knowledge on regulatory mechanisms of leukocyte extravasation from a leukocyte and endothelial point of view, respectively. Specifically, we will focus on highlighting common and unique mechanisms that specific leukocyte subsets exploit to succeed in crossing endothelial monolayers. |
| format | Article |
| id | doaj-art-0af3f4dc67e14e7aa01d9dd5c81b1cda |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-0af3f4dc67e14e7aa01d9dd5c81b1cda2025-02-03T06:05:09ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/946509946509Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during ExtravasationMichael Schnoor0Pilar Alcaide1Mathieu-Benoit Voisin2Jaap D. van Buul3Department of Molecular Biomedicine, Center for Investigation and Advanced Studies of the National Polytechnic Institute (Cinvestav), 07360 Mexico City, DF, MexicoMolecular Cardiology Research Institute, Tufts Medical Center and Tufts University School of Medicine, Boston, MA 02111, USACentre for Microvascular Research, William Harvey Research Institute, Barts & The London SMD, Queen Mary University of London, London EC1M 6BQ, UKDepartment of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, 1066 CX Amsterdam, NetherlandsLeukocyte extravasation is one of the essential and first steps during the initiation of inflammation. Therefore, a better understanding of the key molecules that regulate this process may help to develop novel therapeutics for treatment of inflammation-based diseases such as atherosclerosis or rheumatoid arthritis. The endothelial adhesion molecules ICAM-1 and VCAM-1 are known as the central mediators of leukocyte adhesion to and transmigration across the endothelium. Engagement of these molecules by their leukocyte integrin receptors initiates the activation of several signaling pathways within both leukocytes and endothelium. Several of such events have been described to occur during transendothelial migration of all leukocyte subsets, whereas other mechanisms are known only for a single leukocyte subset. Here, we summarize current knowledge on regulatory mechanisms of leukocyte extravasation from a leukocyte and endothelial point of view, respectively. Specifically, we will focus on highlighting common and unique mechanisms that specific leukocyte subsets exploit to succeed in crossing endothelial monolayers.http://dx.doi.org/10.1155/2015/946509 |
| spellingShingle | Michael Schnoor Pilar Alcaide Mathieu-Benoit Voisin Jaap D. van Buul Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation Mediators of Inflammation |
| title | Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation |
| title_full | Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation |
| title_fullStr | Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation |
| title_full_unstemmed | Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation |
| title_short | Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation |
| title_sort | crossing the vascular wall common and unique mechanisms exploited by different leukocyte subsets during extravasation |
| url | http://dx.doi.org/10.1155/2015/946509 |
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