Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators
The N-methyl-D-aspartate receptors (NMDARs) are subtype glutamate receptors that play important roles in excitatory neurotransmission and synaptic plasticity. Their hypo- or hyperactivation are proposed to contribute to the genesis or progression of various brain diseases, including stroke, schizoph...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/2875904 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550673507418112 |
|---|---|
| author | Lulu Yao Qiang Zhou |
| author_facet | Lulu Yao Qiang Zhou |
| author_sort | Lulu Yao |
| collection | DOAJ |
| description | The N-methyl-D-aspartate receptors (NMDARs) are subtype glutamate receptors that play important roles in excitatory neurotransmission and synaptic plasticity. Their hypo- or hyperactivation are proposed to contribute to the genesis or progression of various brain diseases, including stroke, schizophrenia, depression, and Alzheimer’s disease. Past efforts in targeting NMDARs for therapeutic intervention have largely been on inhibitors of NMDARs. In light of the discovery of NMDAR hypofunction in psychiatric disorders and perhaps Alzheimer’s disease, efforts in boosting NMDAR activity/functions have surged in recent years. In this review, we will focus on enhancing NMDAR functions, especially on the recent progress in the generation of subunit-selective, allosteric positive modulators (PAMs) of NMDARs. We shall also discuss the usefulness of these newly developed NMDAR-PAMs. |
| format | Article |
| id | doaj-art-0ad957920a0f47bb9c3bac2d1c5a5388 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-0ad957920a0f47bb9c3bac2d1c5a53882025-02-03T06:06:00ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/28759042875904Enhancing NMDA Receptor Function: Recent Progress on Allosteric ModulatorsLulu Yao0Qiang Zhou1School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, ChinaSchool of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, ChinaThe N-methyl-D-aspartate receptors (NMDARs) are subtype glutamate receptors that play important roles in excitatory neurotransmission and synaptic plasticity. Their hypo- or hyperactivation are proposed to contribute to the genesis or progression of various brain diseases, including stroke, schizophrenia, depression, and Alzheimer’s disease. Past efforts in targeting NMDARs for therapeutic intervention have largely been on inhibitors of NMDARs. In light of the discovery of NMDAR hypofunction in psychiatric disorders and perhaps Alzheimer’s disease, efforts in boosting NMDAR activity/functions have surged in recent years. In this review, we will focus on enhancing NMDAR functions, especially on the recent progress in the generation of subunit-selective, allosteric positive modulators (PAMs) of NMDARs. We shall also discuss the usefulness of these newly developed NMDAR-PAMs.http://dx.doi.org/10.1155/2017/2875904 |
| spellingShingle | Lulu Yao Qiang Zhou Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators Neural Plasticity |
| title | Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators |
| title_full | Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators |
| title_fullStr | Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators |
| title_full_unstemmed | Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators |
| title_short | Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators |
| title_sort | enhancing nmda receptor function recent progress on allosteric modulators |
| url | http://dx.doi.org/10.1155/2017/2875904 |
| work_keys_str_mv | AT luluyao enhancingnmdareceptorfunctionrecentprogressonallostericmodulators AT qiangzhou enhancingnmdareceptorfunctionrecentprogressonallostericmodulators |