Ion Channels and Zinc: Mechanisms of Neurotoxicity and Neurodegeneration
Ionotropic glutamate receptors, such as NMDA, AMPA and kainate receptors, are ligand-gated ion channels that mediate much of the excitatory neurotransmission in the brain. Not only do these receptors bind glutamate, but they are also regulated by and facilitate the postsynaptic uptake of the trace m...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2012/785647 |
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| author | Deborah R. Morris Cathy W. Levenson |
| author_facet | Deborah R. Morris Cathy W. Levenson |
| author_sort | Deborah R. Morris |
| collection | DOAJ |
| description | Ionotropic glutamate receptors, such as NMDA, AMPA and kainate receptors, are ligand-gated ion channels that mediate much of the excitatory neurotransmission in the brain. Not only do these receptors bind glutamate, but they are also regulated by and facilitate the postsynaptic uptake of the trace metal zinc. This paper discusses the role of the excitotoxic influx and accumulation of zinc, the mechanisms responsible for its cytotoxicity, and a number of disorders of the central nervous system that have been linked to these neuronal ion channels and zinc toxicity including ischemic brain injury, traumatic brain injury, and epilepsy. |
| format | Article |
| id | doaj-art-0ad31a8548a0419f9d5b7ae68052c6e3 |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-0ad31a8548a0419f9d5b7ae68052c6e32025-02-03T01:22:38ZengWileyJournal of Toxicology1687-81911687-82052012-01-01201210.1155/2012/785647785647Ion Channels and Zinc: Mechanisms of Neurotoxicity and NeurodegenerationDeborah R. Morris0Cathy W. Levenson1Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306 4300, USADepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306 4300, USAIonotropic glutamate receptors, such as NMDA, AMPA and kainate receptors, are ligand-gated ion channels that mediate much of the excitatory neurotransmission in the brain. Not only do these receptors bind glutamate, but they are also regulated by and facilitate the postsynaptic uptake of the trace metal zinc. This paper discusses the role of the excitotoxic influx and accumulation of zinc, the mechanisms responsible for its cytotoxicity, and a number of disorders of the central nervous system that have been linked to these neuronal ion channels and zinc toxicity including ischemic brain injury, traumatic brain injury, and epilepsy.http://dx.doi.org/10.1155/2012/785647 |
| spellingShingle | Deborah R. Morris Cathy W. Levenson Ion Channels and Zinc: Mechanisms of Neurotoxicity and Neurodegeneration Journal of Toxicology |
| title | Ion Channels and Zinc: Mechanisms of Neurotoxicity and Neurodegeneration |
| title_full | Ion Channels and Zinc: Mechanisms of Neurotoxicity and Neurodegeneration |
| title_fullStr | Ion Channels and Zinc: Mechanisms of Neurotoxicity and Neurodegeneration |
| title_full_unstemmed | Ion Channels and Zinc: Mechanisms of Neurotoxicity and Neurodegeneration |
| title_short | Ion Channels and Zinc: Mechanisms of Neurotoxicity and Neurodegeneration |
| title_sort | ion channels and zinc mechanisms of neurotoxicity and neurodegeneration |
| url | http://dx.doi.org/10.1155/2012/785647 |
| work_keys_str_mv | AT deborahrmorris ionchannelsandzincmechanismsofneurotoxicityandneurodegeneration AT cathywlevenson ionchannelsandzincmechanismsofneurotoxicityandneurodegeneration |