Polypharmacy driven synergistic toxicities in elderly breast cancer chemotherapy drug management and adverse drug reactions: a mini review

Breast cancer is increasingly diagnosed in older women (median age ≈63 years), and chemotherapy outcomes are clouded by a polypharmacy landscape—defined here as ≥5 concurrent medications—that magnifies toxicity beyond single-agent expectations. Prospective geriatric-oncology cohorts reveal a median...

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Bibliographic Details
Main Authors: Xiran Wang, Jin Yang, Jieying Zhang, Hong Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
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Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1654353/full
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