Gestational diabetes mellitus and offspring’s carotid intima–media thickness at birth: MySweetHeart Cohort study
Objective Hyperglycaemia during pregnancy is associated with cardiometabolic risks for the mother and the offspring. Mothers with gestational diabetes mellitus (GDM) have signs of subclinical atherosclerosis, including increased carotid intima–media thickness (CIMT). We assessed whether GDM is assoc...
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BMJ Publishing Group
2022-07-01
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| Online Access: | https://bmjopen.bmj.com/content/12/7/e061649.full |
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| author | Umberto Simeoni Antje Horsch Arnaud Chiolero Yvan Vial Nicole Sekarski Jardena J Puder Pascal Bovet Stefano Di Bernardo Yvan Mivelaz Adina Mihaela Epure Sandrine Estoppey Younes Bobby Stuijfzand Leah Gilbert Stefano Lanzi Justine Gross Stefano Di Bernardo Dan Quansah Jean-Benoît Rossel Amar Arhab Sandrine Estoppey Younes Seyda Mayerat |
| author_facet | Umberto Simeoni Antje Horsch Arnaud Chiolero Yvan Vial Nicole Sekarski Jardena J Puder Pascal Bovet Stefano Di Bernardo Yvan Mivelaz Adina Mihaela Epure Sandrine Estoppey Younes Bobby Stuijfzand Leah Gilbert Stefano Lanzi Justine Gross Stefano Di Bernardo Dan Quansah Jean-Benoît Rossel Amar Arhab Sandrine Estoppey Younes Seyda Mayerat |
| collection | DOAJ |
| description | Objective Hyperglycaemia during pregnancy is associated with cardiometabolic risks for the mother and the offspring. Mothers with gestational diabetes mellitus (GDM) have signs of subclinical atherosclerosis, including increased carotid intima–media thickness (CIMT). We assessed whether GDM is associated with increased CIMT in the offspring at birth.Design and setting MySweetHeart Cohort is a prospective cohort study conducted in Switzerland.Participants, exposure and outcome measures This work included pregnant women with and without GDM at 24–32 weeks of gestation and their singleton live-born offspring with data on the primary outcome of CIMT. GDM was diagnosed based on the criteria of the International Association of Diabetes and Pregnancy Study Groups. Offspring’s CIMT was measured by ultrasonography after birth (range 1–19 days).Results Data on CIMT were available for 99 offspring of women without GDM and 101 offspring of women with GDM. Maternal age ranged from 18 to 47 years. Some 16% of women with GDM and 6% of women without GDM were obese. Smoking during pregnancy was more frequent among women with GDM (18%) than among those without GDM (4%). Neonatal characteristics were comparable between the two groups. The difference in CIMT between offspring of women with and without GDM was of 0.00 mm (95% CI −0.01 to 0.01; p=0.96) and remained similar on adjustment for potential confounding factors, such as maternal prepregnancy body mass index, maternal education, smoking during pregnancy, family history of diabetes, as well as offspring’s sex, age, and body surface area (0.00 mm (95% CI −0.02 to 0.01; p=0.45)).Conclusions We found no evidence of increased CIMT in neonates exposed to GDM. A longer-term follow-up that includes additional vascular measures, such as endothelial function or arterial stiffness, may shed further light on the cardiovascular health trajectories in children born to mothers with GDM.Trial registration number NCT02872974; Pre-results. |
| format | Article |
| id | doaj-art-0ab5085a205a4a3eacbbe4e345eb82d0 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open |
| spelling | doaj-art-0ab5085a205a4a3eacbbe4e345eb82d02025-01-30T18:40:09ZengBMJ Publishing GroupBMJ Open2044-60552022-07-0112710.1136/bmjopen-2022-061649Gestational diabetes mellitus and offspring’s carotid intima–media thickness at birth: MySweetHeart Cohort study Umberto SimeoniAntje Horsch0Arnaud Chiolero1Yvan Vial2Nicole Sekarski3Jardena J Puder4Pascal Bovet5Stefano Di Bernardo6Yvan Mivelaz7Adina Mihaela Epure8Sandrine Estoppey Younes9Bobby Stuijfzand10Leah Gilbert11Stefano Lanzi12Justine Gross13Stefano Di BernardoDan QuansahJean-Benoît Rossel14Amar Arhab15Sandrine Estoppey YounesSeyda MayeratNeonatology service, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, SwitzerlandPopulation Health Laboratory (#PopHealthLab), University of Fribourg, Fribourg, SwitzerlandObstetrics and Gynecology Service, Woman-Mother-Child Department, Lausanne University Hospital and University of Lausanne, Lausanne, VD, SwitzerlandPaediatric Cardiology Unit, Woman-Mother-Child Department, Lausanne University Hospital and University of Lausanne, Lausanne, VD, SwitzerlandService of Obstetrics, Department Woman Mother Child, University Hospital of Lausanne, Lausanne, Vaud, Switzerland6 Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, SwitzerlandPaediatric Cardiology Unit, Woman-Mother-Child Department, Lausanne University Hospital (CHUV), Lausanne, SwitzerlandPaediatric Cardiology Unit, Woman-Mother-Child Department, Lausanne University Hospital (CHUV), Lausanne, SwitzerlandPopulation Health Laboratory (#PopHealthLab), University of Fribourg, Fribourg, SwitzerlandDepartment of Epidemiology and Health Services, Center for Primary Care and Public Health (UNISANTÉ), University of Lausanne, Lausanne, SwitzerlandObstetric service, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, SwitzerlandObstetric service, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, SwitzerlandHeart and Vessel Department, Division of Angiology, Lausanne University Hospital, Lausanne, SwitzerlandService of Endocrinology, Diabetes and Metabolism, Department of Medicine, Lausanne University Hospital, Lausanne, SwitzerlandUniversity of Bern, Bern, SwitzerlandObstetric service, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, SwitzerlandObjective Hyperglycaemia during pregnancy is associated with cardiometabolic risks for the mother and the offspring. Mothers with gestational diabetes mellitus (GDM) have signs of subclinical atherosclerosis, including increased carotid intima–media thickness (CIMT). We assessed whether GDM is associated with increased CIMT in the offspring at birth.Design and setting MySweetHeart Cohort is a prospective cohort study conducted in Switzerland.Participants, exposure and outcome measures This work included pregnant women with and without GDM at 24–32 weeks of gestation and their singleton live-born offspring with data on the primary outcome of CIMT. GDM was diagnosed based on the criteria of the International Association of Diabetes and Pregnancy Study Groups. Offspring’s CIMT was measured by ultrasonography after birth (range 1–19 days).Results Data on CIMT were available for 99 offspring of women without GDM and 101 offspring of women with GDM. Maternal age ranged from 18 to 47 years. Some 16% of women with GDM and 6% of women without GDM were obese. Smoking during pregnancy was more frequent among women with GDM (18%) than among those without GDM (4%). Neonatal characteristics were comparable between the two groups. The difference in CIMT between offspring of women with and without GDM was of 0.00 mm (95% CI −0.01 to 0.01; p=0.96) and remained similar on adjustment for potential confounding factors, such as maternal prepregnancy body mass index, maternal education, smoking during pregnancy, family history of diabetes, as well as offspring’s sex, age, and body surface area (0.00 mm (95% CI −0.02 to 0.01; p=0.45)).Conclusions We found no evidence of increased CIMT in neonates exposed to GDM. A longer-term follow-up that includes additional vascular measures, such as endothelial function or arterial stiffness, may shed further light on the cardiovascular health trajectories in children born to mothers with GDM.Trial registration number NCT02872974; Pre-results.https://bmjopen.bmj.com/content/12/7/e061649.full |
| spellingShingle | Umberto Simeoni Antje Horsch Arnaud Chiolero Yvan Vial Nicole Sekarski Jardena J Puder Pascal Bovet Stefano Di Bernardo Yvan Mivelaz Adina Mihaela Epure Sandrine Estoppey Younes Bobby Stuijfzand Leah Gilbert Stefano Lanzi Justine Gross Stefano Di Bernardo Dan Quansah Jean-Benoît Rossel Amar Arhab Sandrine Estoppey Younes Seyda Mayerat Gestational diabetes mellitus and offspring’s carotid intima–media thickness at birth: MySweetHeart Cohort study BMJ Open |
| title | Gestational diabetes mellitus and offspring’s carotid intima–media thickness at birth: MySweetHeart Cohort study |
| title_full | Gestational diabetes mellitus and offspring’s carotid intima–media thickness at birth: MySweetHeart Cohort study |
| title_fullStr | Gestational diabetes mellitus and offspring’s carotid intima–media thickness at birth: MySweetHeart Cohort study |
| title_full_unstemmed | Gestational diabetes mellitus and offspring’s carotid intima–media thickness at birth: MySweetHeart Cohort study |
| title_short | Gestational diabetes mellitus and offspring’s carotid intima–media thickness at birth: MySweetHeart Cohort study |
| title_sort | gestational diabetes mellitus and offspring s carotid intima media thickness at birth mysweetheart cohort study |
| url | https://bmjopen.bmj.com/content/12/7/e061649.full |
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