Roles of Oncogenic Long Non-coding RNAs in Cancer Development
Long non-coding RNAs (lncRNAs) are classified as RNAs that are longer than 200 nucleotides and cannot be translated into protein. Several studies have demonstrated that lncRNAs are directly or indirectly involved in a variety of biological processes and in the regulation of gene expression. In addit...
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BioMed Central
2018-12-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gi-2018-16-4-e18.pdf |
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| _version_ | 1832570046566629376 |
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| author | Hyunhee Do Wanyeon Kim |
| author_facet | Hyunhee Do Wanyeon Kim |
| author_sort | Hyunhee Do |
| collection | DOAJ |
| description | Long non-coding RNAs (lncRNAs) are classified as RNAs that are longer than 200 nucleotides and cannot be translated into protein. Several studies have demonstrated that lncRNAs are directly or indirectly involved in a variety of biological processes and in the regulation of gene expression. In addition, lncRNAs have important roles in many diseases including cancer. It has been shown that abnormal expression of lncRNAs is observed in several human solid tumors. Several studies have shown that many lncRNAs can function as oncogenes in cancer development through the induction of cell cycle progression, cell proliferation and invasion, anti-apoptosis, and metastasis. Oncogenic lncRNAs have the potential to become promising biomarkers and might be potent prognostic targets in cancer therapy. However, the biological and molecular mechanisms of lncRNA involvement in tumorigenesis have not yet been fully elucidated. This review summarizes studies on the regulatory and functional roles of oncogenic lncRNAs in the development and progression of various types of cancer. |
| format | Article |
| id | doaj-art-0a9aef35f81247eb839262e4b2bb8052 |
| institution | Kabale University |
| issn | 2234-0742 |
| language | English |
| publishDate | 2018-12-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-0a9aef35f81247eb839262e4b2bb80522025-02-02T17:52:31ZengBioMed CentralGenomics & Informatics2234-07422018-12-0116410.5808/GI.2018.16.4.e18520Roles of Oncogenic Long Non-coding RNAs in Cancer DevelopmentHyunhee DoWanyeon KimLong non-coding RNAs (lncRNAs) are classified as RNAs that are longer than 200 nucleotides and cannot be translated into protein. Several studies have demonstrated that lncRNAs are directly or indirectly involved in a variety of biological processes and in the regulation of gene expression. In addition, lncRNAs have important roles in many diseases including cancer. It has been shown that abnormal expression of lncRNAs is observed in several human solid tumors. Several studies have shown that many lncRNAs can function as oncogenes in cancer development through the induction of cell cycle progression, cell proliferation and invasion, anti-apoptosis, and metastasis. Oncogenic lncRNAs have the potential to become promising biomarkers and might be potent prognostic targets in cancer therapy. However, the biological and molecular mechanisms of lncRNA involvement in tumorigenesis have not yet been fully elucidated. This review summarizes studies on the regulatory and functional roles of oncogenic lncRNAs in the development and progression of various types of cancer.http://genominfo.org/upload/pdf/gi-2018-16-4-e18.pdfbreast cancercolorectal cancerglioblastomalong non-coding RNAnon-small cell lung canceroncogenes |
| spellingShingle | Hyunhee Do Wanyeon Kim Roles of Oncogenic Long Non-coding RNAs in Cancer Development Genomics & Informatics breast cancer colorectal cancer glioblastoma long non-coding RNA non-small cell lung cancer oncogenes |
| title | Roles of Oncogenic Long Non-coding RNAs in Cancer Development |
| title_full | Roles of Oncogenic Long Non-coding RNAs in Cancer Development |
| title_fullStr | Roles of Oncogenic Long Non-coding RNAs in Cancer Development |
| title_full_unstemmed | Roles of Oncogenic Long Non-coding RNAs in Cancer Development |
| title_short | Roles of Oncogenic Long Non-coding RNAs in Cancer Development |
| title_sort | roles of oncogenic long non coding rnas in cancer development |
| topic | breast cancer colorectal cancer glioblastoma long non-coding RNA non-small cell lung cancer oncogenes |
| url | http://genominfo.org/upload/pdf/gi-2018-16-4-e18.pdf |
| work_keys_str_mv | AT hyunheedo rolesofoncogeniclongnoncodingrnasincancerdevelopment AT wanyeonkim rolesofoncogeniclongnoncodingrnasincancerdevelopment |