Model-based prediction of nanoparticle and dissolved form ratios using total concentration data: a case study of SNB-101

Model-based prediction of nanoparticle and dissolved form ratios using total concentration data: a case study of SNB-101

IntroductionIrinotecan (CPT-11), a topoisomerase I inhibitor, serves as a prodrug for SN-38, its active metabolite with significantly higher cytotoxic potency. Despite its clinical efficacy, irinotecan’s therapeutic potential is limited by low fraction of conversion to SN-38, inefficient tumor targe...

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Bibliographic Details
Main Authors: Jinha Park, Soo Hyeon Bae, Sangil Jeon, Young Hwan Park, Dong Cheol Lee, Seunghoon Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
SN-38
nanoparticle drug delivery
pharmacokinetic modeling
tumor targeting
enhanced permeability and retention effect
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1556618/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1556618/full

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