P4HA2 promotes the progression of papillary thyroid cancer by enhancing degradation of IκBα to activate NF-κB signaling pathway

P4HA2 promotes the progression of papillary thyroid cancer by enhancing degradation of IκBα to activate NF-κB signaling pathway

Abstract Papillary thyroid cancer (PTC) is the most common malignancy of the endocrine system. Collagen prolyl 4-hydroxylase alpha subunit 2 (P4HA2) is a key enzyme involved in collagen metabolism. However, the expression and function of P4HA2 in PTC progression have not been well studied. Our previ...

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Bibliographic Details
Main Authors: Ruowen Li, Mingjian Zhao, Min Sun, Yongkang Wu, Chengxu Miao, Liu Fangyu, Mengting Wu, Xiaojia Shi, Jinghui Lu, Xuetian Yue
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cancer Cell International
Subjects:
P4HA2
Papillary thyroid carcinoma
NF-κB signaling pathway
Proteasome degradation
Ubiquitination
Online Access:https://doi.org/10.1186/s12935-025-03871-2
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https://doi.org/10.1186/s12935-025-03871-2

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