Synthesis and Antimicrobial and Antioxidant Activities of Some New 5-(2-Methyl-1H-indol-3-yl)-1,3,4-oxadiazol-2-amine Derivatives
A series of 5-(2-methyl-1H-indol-3-yl)-1,3,4-oxadiazol-2-amine derivatives (3–5) were synthesized. These previously unknown compounds were characterized by spectral studies and elemental analysis. These compounds were evaluated for their antimicrobial and antioxidant activities. Among all the compou...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/148412 |
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| author | Anand R. Saundane Vaijinath A. Verma Vijaykumar T. Katkar |
| author_facet | Anand R. Saundane Vaijinath A. Verma Vijaykumar T. Katkar |
| author_sort | Anand R. Saundane |
| collection | DOAJ |
| description | A series of 5-(2-methyl-1H-indol-3-yl)-1,3,4-oxadiazol-2-amine derivatives (3–5) were synthesized. These previously unknown compounds were characterized by spectral studies and elemental analysis. These compounds were evaluated for their antimicrobial and antioxidant activities. Among all the compounds tested 5d exhibited promising antibacterial, antifungal, radical scavenging, and ferric ions (Fe3+) reducing antioxidant power (FRAP) activities, whereas the compounds 3b, 4c, and 5e exhibited good FRAP and metal chelating activities. In general compounds containing chloro and methyl substituent exhibited better antimicrobial and antioxidant activities. |
| format | Article |
| id | doaj-art-0a8fdea825cd4a96a5415da495a73ab3 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-0a8fdea825cd4a96a5415da495a73ab32025-02-03T01:22:36ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/148412148412Synthesis and Antimicrobial and Antioxidant Activities of Some New 5-(2-Methyl-1H-indol-3-yl)-1,3,4-oxadiazol-2-amine DerivativesAnand R. Saundane0Vaijinath A. Verma1Vijaykumar T. Katkar2Department of Post-Graduate Studies and Research in Chemistry, Gulbarga University, Gulbarga 585 106, IndiaShri Prabhu Arts, Science & J. M. Bohra Commerce Degree College, Shorapur, Karnataka 585 224, IndiaDepartment of Post-Graduate Studies and Research in Chemistry, Gulbarga University, Gulbarga 585 106, IndiaA series of 5-(2-methyl-1H-indol-3-yl)-1,3,4-oxadiazol-2-amine derivatives (3–5) were synthesized. These previously unknown compounds were characterized by spectral studies and elemental analysis. These compounds were evaluated for their antimicrobial and antioxidant activities. Among all the compounds tested 5d exhibited promising antibacterial, antifungal, radical scavenging, and ferric ions (Fe3+) reducing antioxidant power (FRAP) activities, whereas the compounds 3b, 4c, and 5e exhibited good FRAP and metal chelating activities. In general compounds containing chloro and methyl substituent exhibited better antimicrobial and antioxidant activities.http://dx.doi.org/10.1155/2013/148412 |
| spellingShingle | Anand R. Saundane Vaijinath A. Verma Vijaykumar T. Katkar Synthesis and Antimicrobial and Antioxidant Activities of Some New 5-(2-Methyl-1H-indol-3-yl)-1,3,4-oxadiazol-2-amine Derivatives Journal of Chemistry |
| title | Synthesis and Antimicrobial and Antioxidant Activities of Some New 5-(2-Methyl-1H-indol-3-yl)-1,3,4-oxadiazol-2-amine Derivatives |
| title_full | Synthesis and Antimicrobial and Antioxidant Activities of Some New 5-(2-Methyl-1H-indol-3-yl)-1,3,4-oxadiazol-2-amine Derivatives |
| title_fullStr | Synthesis and Antimicrobial and Antioxidant Activities of Some New 5-(2-Methyl-1H-indol-3-yl)-1,3,4-oxadiazol-2-amine Derivatives |
| title_full_unstemmed | Synthesis and Antimicrobial and Antioxidant Activities of Some New 5-(2-Methyl-1H-indol-3-yl)-1,3,4-oxadiazol-2-amine Derivatives |
| title_short | Synthesis and Antimicrobial and Antioxidant Activities of Some New 5-(2-Methyl-1H-indol-3-yl)-1,3,4-oxadiazol-2-amine Derivatives |
| title_sort | synthesis and antimicrobial and antioxidant activities of some new 5 2 methyl 1h indol 3 yl 1 3 4 oxadiazol 2 amine derivatives |
| url | http://dx.doi.org/10.1155/2013/148412 |
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