Genetically Modified Lactococcus lactis for Delivery of Human Interleukin-10 to Dendritic Cells

Genetically Modified Lactococcus lactis for Delivery of Human Interleukin-10 to Dendritic Cells

Interleukin-10 (IL-10) plays an indispensable role in mucosal tolerance by programming dendritic cells (DCs) to induce suppressor Th-cells. We have tested the modulating effect of L. lactis secreting human IL-10 (L. lactisIL-10) on DC function in vitro. Monocyte-derived DC incubated with L. lactis...

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Bibliographic Details
Main Authors:	Inge L. Huibregtse, Sebatian A. Zaat, Martien L. Kapsenberg, Maria A. Sartori da Silva, Maikel P. Peppelenbosch, Sander J. H. van Deventer, Henri Braat
Format:	Article
Language:	English
Published:	Wiley 2012-01-01
Series:	Gastroenterology Research and Practice
Online Access:	http://dx.doi.org/10.1155/2012/639291
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