Aminoguanidine Improved Liver Function and Attenuated Oxidative Stress in Hypothyroid Rats by Propylthiouracil

Aminoguanidine Improved Liver Function and Attenuated Oxidative Stress in Hypothyroid Rats by Propylthiouracil

Background: Hypothyroidism negatively affects liver function, which might be due to nitric oxide (NO) overproduction, oxidative stress, and fibrosis. Aminoguanidine (AMG) as an inducible NO synthase (iNOS) inhibitor attenuates NO and shows antioxidant effects. This study aimed to evaluate the protec...

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Main Authors: Seyed Hamidreza Rastegar-Moghaddam, Zahra Kiumarsi, Alireza Mirani, Mahdieh Mortazavi, Farimah Beheshti, Alireza Ebrahimzadeh-Bideskan, Akbar Anaeigoudari, Mahmoud Hosseini
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-06-01
Series:Advanced Biomedical Research
Subjects:
aminoguanidine
fibrosis
hypothyroidism
liver
oxidative stress
Online Access:https://journals.lww.com/10.4103/abr.abr_538_24
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https://journals.lww.com/10.4103/abr.abr_538_24

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