Current Status of Comprehensive Chromosome Screening for Elective Single-Embryo Transfer
Most in vitro fertilization (IVF) experts and infertility patients agree that the most ideal assisted reproductive technology (ART) outcome is to have a healthy, full-term singleton born. To this end, the most reliable policy is the single-embryo transfer (SET). However, unsatisfactory results in IV...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2014/581783 |
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| author | Ming-Yih Wu Kuang-Han Chao Chin-Der Chen Li-Jung Chang Shee-Uan Chen Yu-Shih Yang |
| author_facet | Ming-Yih Wu Kuang-Han Chao Chin-Der Chen Li-Jung Chang Shee-Uan Chen Yu-Shih Yang |
| author_sort | Ming-Yih Wu |
| collection | DOAJ |
| description | Most in vitro fertilization (IVF) experts and infertility patients agree that the most ideal assisted reproductive technology (ART) outcome is to have a healthy, full-term singleton born. To this end, the most reliable policy is the single-embryo transfer (SET). However, unsatisfactory results in IVF may result from plenty of factors, in which aneuploidy associated with advanced maternal age is a major hurdle. Throughout the past few years, we have got a big leap in advancement of the genetic screening of embryos on aneuploidy, translocation, or mutations. This facilitates a higher success rate in IVF accompanied by the policy of elective SET (eSET). As the cost is lowering while the scale of genome characterization continues to be up over the recent years, the contemporary technologies on trophectoderm biopsy and freezing-thaw, comprehensive chromosome screening (CCS) with eSET appear to be getting more and more popular for modern IVF centers. Furthermore, evidence has showen that, by these avant-garde techniques (trophectoderm biopsy, vitrification, and CCS), older infertile women with the help of eSET may have an opportunity to increase the success of their live birth rates approaching those reported in younger infertility patients. |
| format | Article |
| id | doaj-art-0a614ab6a5ef4ca6b94bc2b71df2665e |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-0a614ab6a5ef4ca6b94bc2b71df2665e2025-02-03T07:24:20ZengWileyObstetrics and Gynecology International1687-95891687-95972014-01-01201410.1155/2014/581783581783Current Status of Comprehensive Chromosome Screening for Elective Single-Embryo TransferMing-Yih Wu0Kuang-Han Chao1Chin-Der Chen2Li-Jung Chang3Shee-Uan Chen4Yu-Shih Yang5Department of Obstetrics and Gynecology, National Taiwan University Hospital and College of Medicine, 7 Chung-Shan South Road, Taipei 10002, TaiwanDepartment of Obstetrics and Gynecology, National Taiwan University Hospital and College of Medicine, 7 Chung-Shan South Road, Taipei 10002, TaiwanDepartment of Obstetrics and Gynecology, National Taiwan University Hospital and College of Medicine, 7 Chung-Shan South Road, Taipei 10002, TaiwanDepartment of Obstetrics and Gynecology, National Taiwan University Hospital and College of Medicine, 7 Chung-Shan South Road, Taipei 10002, TaiwanDepartment of Obstetrics and Gynecology, National Taiwan University Hospital and College of Medicine, 7 Chung-Shan South Road, Taipei 10002, TaiwanDepartment of Obstetrics and Gynecology, National Taiwan University Hospital and College of Medicine, 7 Chung-Shan South Road, Taipei 10002, TaiwanMost in vitro fertilization (IVF) experts and infertility patients agree that the most ideal assisted reproductive technology (ART) outcome is to have a healthy, full-term singleton born. To this end, the most reliable policy is the single-embryo transfer (SET). However, unsatisfactory results in IVF may result from plenty of factors, in which aneuploidy associated with advanced maternal age is a major hurdle. Throughout the past few years, we have got a big leap in advancement of the genetic screening of embryos on aneuploidy, translocation, or mutations. This facilitates a higher success rate in IVF accompanied by the policy of elective SET (eSET). As the cost is lowering while the scale of genome characterization continues to be up over the recent years, the contemporary technologies on trophectoderm biopsy and freezing-thaw, comprehensive chromosome screening (CCS) with eSET appear to be getting more and more popular for modern IVF centers. Furthermore, evidence has showen that, by these avant-garde techniques (trophectoderm biopsy, vitrification, and CCS), older infertile women with the help of eSET may have an opportunity to increase the success of their live birth rates approaching those reported in younger infertility patients.http://dx.doi.org/10.1155/2014/581783 |
| spellingShingle | Ming-Yih Wu Kuang-Han Chao Chin-Der Chen Li-Jung Chang Shee-Uan Chen Yu-Shih Yang Current Status of Comprehensive Chromosome Screening for Elective Single-Embryo Transfer Obstetrics and Gynecology International |
| title | Current Status of Comprehensive Chromosome Screening for Elective Single-Embryo Transfer |
| title_full | Current Status of Comprehensive Chromosome Screening for Elective Single-Embryo Transfer |
| title_fullStr | Current Status of Comprehensive Chromosome Screening for Elective Single-Embryo Transfer |
| title_full_unstemmed | Current Status of Comprehensive Chromosome Screening for Elective Single-Embryo Transfer |
| title_short | Current Status of Comprehensive Chromosome Screening for Elective Single-Embryo Transfer |
| title_sort | current status of comprehensive chromosome screening for elective single embryo transfer |
| url | http://dx.doi.org/10.1155/2014/581783 |
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