The Expression of <i>Shmt</i> Genes in Amphioxus Suggests a Role in Tissue Proliferation Rather than in Neurotransmission

The Expression of <i>Shmt</i> Genes in Amphioxus Suggests a Role in Tissue Proliferation Rather than in Neurotransmission

Serine hydroxymethyltransferases (SHMTs) are key enzymes in one-carbon metabolism, with vertebrates possessing two paralogs, cytosolic SHMT1 and mitochondrial SHMT2, implicated in nucleotide biosynthesis and glycine metabolism. In this study, we investigate the evolutionary history of animal <i&g...

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Main Authors: Matteo Bozzo, Emanuele Serafini, Giacomo Rosa, Virginia Bazzurro, Andrea Amaroli, Sara Ferrando, Michael Schubert, Simona Candiani
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
glycine biosynthesis
development
evolution
serine hydroxymethyltransferase
glycinergic neurons
one-carbon metabolism
Online Access:https://www.mdpi.com/2073-4409/14/14/1071
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