Case Report: Metastatic small bowel adenocarcinoma with DNA mismatch repair deficiency in an organ transplant recipient treated with anti-PD-1 immunotherapy

Case Report: Metastatic small bowel adenocarcinoma with DNA mismatch repair deficiency in an organ transplant recipient treated with anti-PD-1 immunotherapy

We present a case of a 65-year-old woman with a history of kidney and pancreas transplants for type 1 diabetes mellitus who presented with small bowel obstruction and was found to have a poorly differentiated small bowel adenocarcinoma with multifocal osseous and nodal metastases. Plasma-based next...

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Bibliographic Details
Main Authors: Quan H. Phung, Alexander K. Tsai, Byoung U. Park, Robben Schat, Richard Spong, L. Jill Tsai, Amit A. Kulkarni, Emmanuel S. Antonarakis, Arjun Gupta
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Oncology
Subjects:
immunotherapy
DNA mismatch repair
tumor mutational burden
allograft transplant
gastrointestinal cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1579364/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1579364/full

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