Case Report: Diazoxide-induced diabetic ketoacidosis in a patient with insulinoma
Definitive management of insulinoma is challenging as curative surgery is associated with a considerable risk of morbidity and mortality. The successful long-term use of diazoxide for patients diagnosed with insulinoma has been described, but rarely, the use of diazoxide can be complicated by diabet...
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| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1524288/full |
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| author | Run Ting Chin Jolene Jiayu Kiew Khek Yu Ho Doddabele S. Deepak |
| author_facet | Run Ting Chin Jolene Jiayu Kiew Khek Yu Ho Doddabele S. Deepak |
| author_sort | Run Ting Chin |
| collection | DOAJ |
| description | Definitive management of insulinoma is challenging as curative surgery is associated with a considerable risk of morbidity and mortality. The successful long-term use of diazoxide for patients diagnosed with insulinoma has been described, but rarely, the use of diazoxide can be complicated by diabetic ketoacidosis (DKA). This case report describes a frail elderly patient with high surgical risk diagnosed with pancreatic head insulinoma whose initial treatment with diazoxide was complicated by a hyperglycemic crisis. Her insulinoma was eventually managed with endoscopic ultrasound-guided-radiofrequency ablation (EUS-RFA) with complete resolution of hypoglycemic episodes. This case highlights the importance of monitoring for side effects of diazoxide, especially in the elderly, and the role of EUS-RFA as an emerging non-surgical treatment modality for insulinoma. |
| format | Article |
| id | doaj-art-0a33a1d2ac064718a4f9b828c681e35d |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-0a33a1d2ac064718a4f9b828c681e35d2025-08-20T03:51:58ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-05-011610.3389/fendo.2025.15242881524288Case Report: Diazoxide-induced diabetic ketoacidosis in a patient with insulinomaRun Ting Chin0Jolene Jiayu Kiew1Khek Yu Ho2Doddabele S. Deepak3Division of Endocrinology, Department of Medicine, National University Hospital, National University Health Systems, Singapore, SingaporeDivision of Endocrinology, Department of Medicine, Ng Teng Fong General Hospital, National University Health Systems, Singapore, SingaporeDivision of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, National University Health Systems, Singapore, SingaporeDivision of Endocrinology, Department of Medicine, National University Hospital, National University Health Systems, Singapore, SingaporeDefinitive management of insulinoma is challenging as curative surgery is associated with a considerable risk of morbidity and mortality. The successful long-term use of diazoxide for patients diagnosed with insulinoma has been described, but rarely, the use of diazoxide can be complicated by diabetic ketoacidosis (DKA). This case report describes a frail elderly patient with high surgical risk diagnosed with pancreatic head insulinoma whose initial treatment with diazoxide was complicated by a hyperglycemic crisis. Her insulinoma was eventually managed with endoscopic ultrasound-guided-radiofrequency ablation (EUS-RFA) with complete resolution of hypoglycemic episodes. This case highlights the importance of monitoring for side effects of diazoxide, especially in the elderly, and the role of EUS-RFA as an emerging non-surgical treatment modality for insulinoma.https://www.frontiersin.org/articles/10.3389/fendo.2025.1524288/fullinsulinomadiazoxidediabetic ketoacidosisendoscopic ultrasoundradiofrequency ablation |
| spellingShingle | Run Ting Chin Jolene Jiayu Kiew Khek Yu Ho Doddabele S. Deepak Case Report: Diazoxide-induced diabetic ketoacidosis in a patient with insulinoma Frontiers in Endocrinology insulinoma diazoxide diabetic ketoacidosis endoscopic ultrasound radiofrequency ablation |
| title | Case Report: Diazoxide-induced diabetic ketoacidosis in a patient with insulinoma |
| title_full | Case Report: Diazoxide-induced diabetic ketoacidosis in a patient with insulinoma |
| title_fullStr | Case Report: Diazoxide-induced diabetic ketoacidosis in a patient with insulinoma |
| title_full_unstemmed | Case Report: Diazoxide-induced diabetic ketoacidosis in a patient with insulinoma |
| title_short | Case Report: Diazoxide-induced diabetic ketoacidosis in a patient with insulinoma |
| title_sort | case report diazoxide induced diabetic ketoacidosis in a patient with insulinoma |
| topic | insulinoma diazoxide diabetic ketoacidosis endoscopic ultrasound radiofrequency ablation |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1524288/full |
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