Gut Microbiota and Type 2 Diabetes Mellitus: Association, Mechanism, and Translational Applications
Gut microbiota has attracted widespread attention due to its crucial role in disease pathophysiology, including type 2 diabetes mellitus (T2DM). Metabolites and bacterial components of gut microbiota affect the initiation and progression of T2DM by regulating inflammation, immunity, and metabolism....
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2021/5110276 |
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| _version_ | 1832565211925577728 |
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| author | Lili Zhang Jinjin Chu Wenhao Hao Jiaojiao Zhang Haibo Li Chunjuan Yang Jinghan Yang Xiaohua Chen Honggang Wang |
| author_facet | Lili Zhang Jinjin Chu Wenhao Hao Jiaojiao Zhang Haibo Li Chunjuan Yang Jinghan Yang Xiaohua Chen Honggang Wang |
| author_sort | Lili Zhang |
| collection | DOAJ |
| description | Gut microbiota has attracted widespread attention due to its crucial role in disease pathophysiology, including type 2 diabetes mellitus (T2DM). Metabolites and bacterial components of gut microbiota affect the initiation and progression of T2DM by regulating inflammation, immunity, and metabolism. Short-chain fatty acids, secondary bile acid, imidazole propionate, branched-chain amino acids, and lipopolysaccharide are the main molecules related to T2DM. Many studies have investigated the role of gut microbiota in T2DM, particularly those butyrate-producing bacteria. Increasing evidence has demonstrated that fecal microbiota transplantation and probiotic capsules are useful strategies in preventing diabetes. In this review, we aim to elucidate the complex association between gut microbiota and T2DM inflammation, metabolism, and immune disorders, the underlying mechanisms, and translational applications of gut microbiota. This review will provide novel insight into developing individualized therapy for T2DM patients based on gut microbiota immunometabolism. |
| format | Article |
| id | doaj-art-0a2764593f0e4281a2eb00fe7c337ff3 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-0a2764593f0e4281a2eb00fe7c337ff32025-02-03T01:08:48ZengWileyMediators of Inflammation0962-93511466-18612021-01-01202110.1155/2021/51102765110276Gut Microbiota and Type 2 Diabetes Mellitus: Association, Mechanism, and Translational ApplicationsLili Zhang0Jinjin Chu1Wenhao Hao2Jiaojiao Zhang3Haibo Li4Chunjuan Yang5Jinghan Yang6Xiaohua Chen7Honggang Wang8Central Laboratory, Weifang People’s Hospital, Weifang 261000, ChinaCentral Laboratory, Weifang People’s Hospital, Weifang 261000, ChinaDepartment of Scientific Research Management, Weifang People’s Hospital, Weifang 261000, ChinaCentral Laboratory, Weifang People’s Hospital, Weifang 261000, ChinaCentral Laboratory, Weifang People’s Hospital, Weifang 261000, ChinaCentral Laboratory of the First Affiliated Hospital, Weifang Medical University, Weifang 261000, ChinaCentral Laboratory of the First Affiliated Hospital, Weifang Medical University, Weifang 261000, ChinaDepartment of Nuclear Medicine, Weifang People’s Hospital, Weifang 261000, ChinaClinical Laboratory, Weifang People’s Hospital, Weifang 261000, ChinaGut microbiota has attracted widespread attention due to its crucial role in disease pathophysiology, including type 2 diabetes mellitus (T2DM). Metabolites and bacterial components of gut microbiota affect the initiation and progression of T2DM by regulating inflammation, immunity, and metabolism. Short-chain fatty acids, secondary bile acid, imidazole propionate, branched-chain amino acids, and lipopolysaccharide are the main molecules related to T2DM. Many studies have investigated the role of gut microbiota in T2DM, particularly those butyrate-producing bacteria. Increasing evidence has demonstrated that fecal microbiota transplantation and probiotic capsules are useful strategies in preventing diabetes. In this review, we aim to elucidate the complex association between gut microbiota and T2DM inflammation, metabolism, and immune disorders, the underlying mechanisms, and translational applications of gut microbiota. This review will provide novel insight into developing individualized therapy for T2DM patients based on gut microbiota immunometabolism.http://dx.doi.org/10.1155/2021/5110276 |
| spellingShingle | Lili Zhang Jinjin Chu Wenhao Hao Jiaojiao Zhang Haibo Li Chunjuan Yang Jinghan Yang Xiaohua Chen Honggang Wang Gut Microbiota and Type 2 Diabetes Mellitus: Association, Mechanism, and Translational Applications Mediators of Inflammation |
| title | Gut Microbiota and Type 2 Diabetes Mellitus: Association, Mechanism, and Translational Applications |
| title_full | Gut Microbiota and Type 2 Diabetes Mellitus: Association, Mechanism, and Translational Applications |
| title_fullStr | Gut Microbiota and Type 2 Diabetes Mellitus: Association, Mechanism, and Translational Applications |
| title_full_unstemmed | Gut Microbiota and Type 2 Diabetes Mellitus: Association, Mechanism, and Translational Applications |
| title_short | Gut Microbiota and Type 2 Diabetes Mellitus: Association, Mechanism, and Translational Applications |
| title_sort | gut microbiota and type 2 diabetes mellitus association mechanism and translational applications |
| url | http://dx.doi.org/10.1155/2021/5110276 |
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