The Current Applications of Metabolomics in Understanding Endometriosis: A Systematic Review
Endometriosis is a common gynecological disease that affects approximately 10–15% of reproductive-aged women worldwide. This debilitating disease has a negative impact on the quality of life of those affected. Despite this condition being very common, the pathogenesis is not well understood. Metabol...
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2025-01-01
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| author | Blake Collie Jacopo Troisi Martina Lombardi Steven Symes Sean Richards |
| author_facet | Blake Collie Jacopo Troisi Martina Lombardi Steven Symes Sean Richards |
| author_sort | Blake Collie |
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| description | Endometriosis is a common gynecological disease that affects approximately 10–15% of reproductive-aged women worldwide. This debilitating disease has a negative impact on the quality of life of those affected. Despite this condition being very common, the pathogenesis is not well understood. Metabolomics is the study of the array of low-weight metabolites in a given sample. This emerging field of omics-based science has proved to be effective at furthering the understanding of endometriosis. In this systematic review, we seek to provide an overview of the application of metabolomics in endometriosis. We highlight the use of metabolomics in locating biomarkers for identification, understanding treatment mechanisms and symptoms, and relating external factors to endometriosis. The literature search took place in the Web of Science, Pubmed, and Google Scholar based on the keywords “metabolomics” AND “endometriosis” or “metabolome” AND “endometriosis”. We found 58 articles from 2012 to 2024 that met our search criteria. Significant alterations of lipids, amino acids, as well as other compounds were present in human and animal models. Discrepancies among studies of significantly altered metabolites make it difficult to make general conclusions on the metabolic signature of endometriosis. However, several individual metabolites were elevated in multiple studies of women with endometriosis; these include 3-hydroxybutyrate, lactate, phosphatidic acids, succinate, pyruvate, tetradecenoylcarnitine, hypoxanthine, and xanthine. Accordingly, L-isoleucine and citrate were reduced in multiple studies of women with endometriosis. Including larger cohorts, standardizing testing methods, and studying the individual phenotypes of endometriosis may lead to more separable results. |
| format | Article |
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| institution | Kabale University |
| issn | 2218-1989 |
| language | English |
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| spelling | doaj-art-0a0d9ad6a0a248e282835def91b50ec62025-01-24T13:41:17ZengMDPI AGMetabolites2218-19892025-01-011515010.3390/metabo15010050The Current Applications of Metabolomics in Understanding Endometriosis: A Systematic ReviewBlake Collie0Jacopo Troisi1Martina Lombardi2Steven Symes3Sean Richards4Department of Biology, University of Tennessee at Chattanooga, Chattanooga, TN 37403, USA Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyDepartment of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyDepartment of Chemistry and Physics, University of Tennessee at Chattanooga, Chattanooga, TN 37403, USASection on Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Tennessee College of Medicine, Chattanooga, TN 37403, USAEndometriosis is a common gynecological disease that affects approximately 10–15% of reproductive-aged women worldwide. This debilitating disease has a negative impact on the quality of life of those affected. Despite this condition being very common, the pathogenesis is not well understood. Metabolomics is the study of the array of low-weight metabolites in a given sample. This emerging field of omics-based science has proved to be effective at furthering the understanding of endometriosis. In this systematic review, we seek to provide an overview of the application of metabolomics in endometriosis. We highlight the use of metabolomics in locating biomarkers for identification, understanding treatment mechanisms and symptoms, and relating external factors to endometriosis. The literature search took place in the Web of Science, Pubmed, and Google Scholar based on the keywords “metabolomics” AND “endometriosis” or “metabolome” AND “endometriosis”. We found 58 articles from 2012 to 2024 that met our search criteria. Significant alterations of lipids, amino acids, as well as other compounds were present in human and animal models. Discrepancies among studies of significantly altered metabolites make it difficult to make general conclusions on the metabolic signature of endometriosis. However, several individual metabolites were elevated in multiple studies of women with endometriosis; these include 3-hydroxybutyrate, lactate, phosphatidic acids, succinate, pyruvate, tetradecenoylcarnitine, hypoxanthine, and xanthine. Accordingly, L-isoleucine and citrate were reduced in multiple studies of women with endometriosis. Including larger cohorts, standardizing testing methods, and studying the individual phenotypes of endometriosis may lead to more separable results.https://www.mdpi.com/2218-1989/15/1/50endometriosismetabolomicslipidomicsbiomarker |
| spellingShingle | Blake Collie Jacopo Troisi Martina Lombardi Steven Symes Sean Richards The Current Applications of Metabolomics in Understanding Endometriosis: A Systematic Review Metabolites endometriosis metabolomics lipidomics biomarker |
| title | The Current Applications of Metabolomics in Understanding Endometriosis: A Systematic Review |
| title_full | The Current Applications of Metabolomics in Understanding Endometriosis: A Systematic Review |
| title_fullStr | The Current Applications of Metabolomics in Understanding Endometriosis: A Systematic Review |
| title_full_unstemmed | The Current Applications of Metabolomics in Understanding Endometriosis: A Systematic Review |
| title_short | The Current Applications of Metabolomics in Understanding Endometriosis: A Systematic Review |
| title_sort | current applications of metabolomics in understanding endometriosis a systematic review |
| topic | endometriosis metabolomics lipidomics biomarker |
| url | https://www.mdpi.com/2218-1989/15/1/50 |
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