Formulation of Salam (Syzygium polyanthum (wight) walp) Leaves Ethanolic Extract Matrix Patch and Its Evaluation
The total flavonoid content in salam leaves has an anti-inflammatory activity at a dose of 2.1% w/w. For topical anti-inflammatory, a matrix patch has a delivery mechanism that drugs pass through in the skin in a controlled for an extended period. Polymers were the patch's main component to con...
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LPPT Universitas Gadjah Mada
2024-04-01
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| Series: | Journal of Food and Pharmaceutical Sciences |
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| Online Access: | https://jurnal.ugm.ac.id/v3/JFPS/article/view/9011/4119 |
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| author | Dian Eka Ermawati Novi Andriani Ulfa Afrinurfadhilah Darojati |
| author_facet | Dian Eka Ermawati Novi Andriani Ulfa Afrinurfadhilah Darojati |
| author_sort | Dian Eka Ermawati |
| collection | DOAJ |
| description | The total flavonoid content in salam leaves has an anti-inflammatory activity at a dose of 2.1% w/w. For topical anti-inflammatory, a matrix patch has a delivery mechanism that drugs pass through in the skin in a controlled for an extended period. Polymers were the patch's main component to control the drug release. Polyvinyl alcohol (PVA) and alpha-cellulose (AC) were polymers that can increase the rate of drug diffusion and form a strong film layer. Salam leaves were extracted by maceration using ethanol 96%. Matrix patches were made with a combination of PVA and AC in ratios 1:1; 3:1; 1:3. The patches were tested for physicochemical properties. The stability test was conducted at 4, 25, and 40 temperatures for 8 h, respectively. Statistical analysis of the test data used One Way ANOVA with a confidence level of 95%. The results showed that the high concentration of PVA significantly affected the weight and moisture content but did not affect the organoleptic thickness, folding endurance, and pH of the matrix patch. The best matrix patch of salam leaves ethanolic extract was PVA and AC of 3:1 because it met the requirements for the matrix patch, including the weight of 1.96-2.06 grams, thickness of 1.15-1.18 mm, folding endurance >300 times, humidity 25.75 – 30.17% and pH 6.3 – 7.1. The patch contains flavonoids with Rf values for extract and patch of 0.95 and 0.96, respectively. Further study, in vivo anti-inflammatory test is necessary. |
| format | Article |
| id | doaj-art-09e3d77294f74af588664593b1442d1c |
| institution | Kabale University |
| issn | 2089-7200 2339-0948 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | LPPT Universitas Gadjah Mada |
| record_format | Article |
| series | Journal of Food and Pharmaceutical Sciences |
| spelling | doaj-art-09e3d77294f74af588664593b1442d1c2025-01-24T08:27:55ZengLPPT Universitas Gadjah MadaJournal of Food and Pharmaceutical Sciences2089-72002339-09482024-04-01121182710.22146/jfps.9011Formulation of Salam (Syzygium polyanthum (wight) walp) Leaves Ethanolic Extract Matrix Patch and Its EvaluationDian Eka Ermawati0Novi Andriani1Ulfa Afrinurfadhilah Darojati2Department of Pharmacy, Vocational School, Universitas Sebelas Maret, Surakarta, Central Java, Indonesia, Jalan Ir. Sutami 36 A Kentingan, SurakartaDepartment of Pharmacy, Vocational School, Universitas Sebelas Maret, Surakarta, Central Java, Indonesia, Jalan Ir. Sutami 36 A Kentingan, SurakartaDepartment of Pharmacy, Vocational School, Universitas Sebelas Maret, Surakarta, Central Java, Indonesia, Jalan Ir. Sutami 36 A Kentingan, SurakartaThe total flavonoid content in salam leaves has an anti-inflammatory activity at a dose of 2.1% w/w. For topical anti-inflammatory, a matrix patch has a delivery mechanism that drugs pass through in the skin in a controlled for an extended period. Polymers were the patch's main component to control the drug release. Polyvinyl alcohol (PVA) and alpha-cellulose (AC) were polymers that can increase the rate of drug diffusion and form a strong film layer. Salam leaves were extracted by maceration using ethanol 96%. Matrix patches were made with a combination of PVA and AC in ratios 1:1; 3:1; 1:3. The patches were tested for physicochemical properties. The stability test was conducted at 4, 25, and 40 temperatures for 8 h, respectively. Statistical analysis of the test data used One Way ANOVA with a confidence level of 95%. The results showed that the high concentration of PVA significantly affected the weight and moisture content but did not affect the organoleptic thickness, folding endurance, and pH of the matrix patch. The best matrix patch of salam leaves ethanolic extract was PVA and AC of 3:1 because it met the requirements for the matrix patch, including the weight of 1.96-2.06 grams, thickness of 1.15-1.18 mm, folding endurance >300 times, humidity 25.75 – 30.17% and pH 6.3 – 7.1. The patch contains flavonoids with Rf values for extract and patch of 0.95 and 0.96, respectively. Further study, in vivo anti-inflammatory test is necessary.https://jurnal.ugm.ac.id/v3/JFPS/article/view/9011/4119polyvinylalcoholalpha-cellulosepatchphysicochemical propertiespolymer |
| spellingShingle | Dian Eka Ermawati Novi Andriani Ulfa Afrinurfadhilah Darojati Formulation of Salam (Syzygium polyanthum (wight) walp) Leaves Ethanolic Extract Matrix Patch and Its Evaluation Journal of Food and Pharmaceutical Sciences polyvinylalcohol alpha-cellulose patch physicochemical properties polymer |
| title | Formulation of Salam (Syzygium polyanthum (wight) walp) Leaves Ethanolic Extract Matrix Patch and Its Evaluation |
| title_full | Formulation of Salam (Syzygium polyanthum (wight) walp) Leaves Ethanolic Extract Matrix Patch and Its Evaluation |
| title_fullStr | Formulation of Salam (Syzygium polyanthum (wight) walp) Leaves Ethanolic Extract Matrix Patch and Its Evaluation |
| title_full_unstemmed | Formulation of Salam (Syzygium polyanthum (wight) walp) Leaves Ethanolic Extract Matrix Patch and Its Evaluation |
| title_short | Formulation of Salam (Syzygium polyanthum (wight) walp) Leaves Ethanolic Extract Matrix Patch and Its Evaluation |
| title_sort | formulation of salam syzygium polyanthum wight walp leaves ethanolic extract matrix patch and its evaluation |
| topic | polyvinylalcohol alpha-cellulose patch physicochemical properties polymer |
| url | https://jurnal.ugm.ac.id/v3/JFPS/article/view/9011/4119 |
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