Evolution of SARS-CoV-2 antibody repertoire after successive mRNA vaccinations under immunosuppressive treatmentResearch in context

Evolution of SARS-CoV-2 antibody repertoire after successive mRNA vaccinations under immunosuppressive treatmentResearch in context

Summary: Background: Repeated antigen exposure can result in a shifting antibody repertoire. The mechanisms by which this occurs and consequences for cross-variant protection against evolving pathogens remain incompletely understood, particularly in the context of immunosuppressive treatments used...

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Main Authors: Jim B.D. Keijser, Eileen W. Stalman, Luuk Wieske, Maurice Steenhuis, Koos P.J. van Dam, Laura Y.L. Kummer, Zoé L.E. van Kempen, Joep Killestein, Adriaan G. Volkers, Sander W. Tas, Laura Boekel, Gerrit J. Wolbink, Laura Fernandez Blanco, Niels J.M. Verstegen, Sofie Keijzer, Gerard van Mierlo, Olvi Cristianawati, Arend J. Boogaard, Karlijn van der Straten, Jacqueline van Rijswijk, Marit J. van Gils, Anja ten Brinke, S. Marieke van Ham, Taco W. Kuijpers, Filip Eftimov, Theo Rispens, Anneke J. Van der Kooi, Joop Raaphorst, Mark Löwenberg, R. Bart Takkenberg, Geert R.A.M. D'Haens, Phyllis I. Spuls, Marcel W. Bekkenk, Annelie H. Musters, Nicoline F. Post, Angela L. Bosma, Marc L. Hilhorst, Yosta Vegting, Frederike J. Bemelman, Alexandre E. Voskuyl, Bo Broens, Agner R. Parra Sanchez, Cécile A.C.M. Van Els, Jelle De Wit, Abraham Rutgers, Karina De Leeuw, Barbara Horváth, Jan J.G.M. Verschuuren, Annabel M. Ruiter, Lotte Van Ouwerkerk, Diane Van der Woude, Renée C.F. Van Allaart, Y.K. Onno Teng, Pieter Van Paassen, Matthias H. Busch, Papay B.P. Jallah, Esther Brusse, Pieter A. Van Doorn, Adája E. Baars, Dirk Jan Hijnen, Corine R.G. Schreurs, W. Ludo Van der Pol, H. Stephan Goedee, Koos A.H. Zwinderman, Rivka De Jongh, Carolien E. Van de Sandt, Lisan H. Kuijper, Mariël C. Duurland, Ruth R. Hagen, Jet Van den Dijssel, Christine Kreher, Amélie V. Bos, Virginia Palomares Cabeza, Veronique A.L. Konijn, George Elias, Elham S. Mirfazeli
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:EBioMedicine
Subjects:
Antibody repertoire
mRNA vaccines
Serology
SARS-CoV-2
Autoimmune disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425000647
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