Sex-dependent epigenetic disruption of YY1 binding by prenatal BPA exposure downregulates Matr3 and alters Agap1 splicing in the offspring hippocampus

Sex-dependent epigenetic disruption of YY1 binding by prenatal BPA exposure downregulates Matr3 and alters Agap1 splicing in the offspring hippocampus

Abstract Background Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by impairments in communication, social interaction, and behavior. Its etiology involves a combination of genetic and environmental factors, and it is more prevalent in males. Bisphenol A (BPA), an end...

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Main Authors: Pattanachat Lertpeerapan, Songphon Kanlayaprasit, Surangrat Thongkorn, Kasidit Kasitipradit, Pawinee Panjabud, Kwanjira Songsritaya, Thanawin Jantheang, Masanobu Morita, Takaaki Akaike, Valerie W. Hu, Depicha Jindatip, Thanit Saeliw, Tewarit Sarachana
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Biology of Sex Differences
Subjects:
Autism spectrum disorder
Bisphenol A
Alternative splicing
Agap1
RNA-binding protein
Matr3
Online Access:https://doi.org/10.1186/s13293-025-00744-1
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https://doi.org/10.1186/s13293-025-00744-1

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