Identification of TUBB3 as an immunotherapy target in lung cancer by genome wide in vivo CRISPR screening

Identification of TUBB3 as an immunotherapy target in lung cancer by genome wide in vivo CRISPR screening

Recent development of immune checkpoint inhibitors has revolutionized cancer immunotherapy. Although these drugs show dramatic effects on a subset of cancer patients, many other tumors are non-responsive and the pathological mechanism of the resistance is largely unknown. To identify genes underlyin...

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Bibliographic Details
Main Authors: Dan Zhao, Ravindra Deshpande, Kerui Wu, Abhishek Tyagi, Sambad Sharma, Shih-Ying Wu, Fei Xing, Stacey O'Neill, Jimmy Ruiz, Feng Lyu, Kounosuke Watabe
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
In vivo CRISPR screening
TUBB3
Anti-PD-1
PDL-1
Lung cancer immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558624001416
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