Antioxidant and Anti-Inflammatory Properties of Melatonin in Secondary Traumatic Brain Injury
Traumatic brain injury (TBI) is a disease resulting from external physical forces acting against the head, leading to transient or chronic damage to brain tissue. Primary brain injury is an immediate and, therefore, rather irreversible effect of trauma, while secondary brain injury results from a co...
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| Format: | Article |
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MDPI AG
2024-12-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/14/1/25 |
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| author | Mariusz Sieminski Michalina Reimus Maria Kałas Ewelina Stępniewska |
| author_facet | Mariusz Sieminski Michalina Reimus Maria Kałas Ewelina Stępniewska |
| author_sort | Mariusz Sieminski |
| collection | DOAJ |
| description | Traumatic brain injury (TBI) is a disease resulting from external physical forces acting against the head, leading to transient or chronic damage to brain tissue. Primary brain injury is an immediate and, therefore, rather irreversible effect of trauma, while secondary brain injury results from a complex cascade of pathological processes, among which oxidative stress and neuroinflammation are the most prominent. As TBI is a significant cause of mortality and chronic disability, with high social costs all over the world, any form of therapy that may mitigate trauma-evoked brain damage is desirable. Melatonin, a sleep–wake-cycle-regulating neurohormone, exerts strong antioxidant and anti-inflammatory effects and is well tolerated when used as a drug. Due to these properties, it is very reasonable to consider melatonin as a potential therapeutic molecule for TBI treatment. This review summarizes data from in vitro studies, animal models, and clinical trials that focus on the usage of melatonin in TBI. |
| format | Article |
| id | doaj-art-08e6c5fe37f541c3beb4f00981ee23b4 |
| institution | Kabale University |
| issn | 2076-3921 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-08e6c5fe37f541c3beb4f00981ee23b42025-01-24T13:19:11ZengMDPI AGAntioxidants2076-39212024-12-011412510.3390/antiox14010025Antioxidant and Anti-Inflammatory Properties of Melatonin in Secondary Traumatic Brain InjuryMariusz Sieminski0Michalina Reimus1Maria Kałas2Ewelina Stępniewska3Department of Emergency Medicine, Medical University of Gdańsk, 80-214 Gdańsk, PolandEmergency Department, University Clinical Center, 80-952 Gdańsk, PolandDepartment of Emergency Medicine, Medical University of Gdańsk, 80-214 Gdańsk, PolandDepartment of Emergency Medicine, Medical University of Gdańsk, 80-214 Gdańsk, PolandTraumatic brain injury (TBI) is a disease resulting from external physical forces acting against the head, leading to transient or chronic damage to brain tissue. Primary brain injury is an immediate and, therefore, rather irreversible effect of trauma, while secondary brain injury results from a complex cascade of pathological processes, among which oxidative stress and neuroinflammation are the most prominent. As TBI is a significant cause of mortality and chronic disability, with high social costs all over the world, any form of therapy that may mitigate trauma-evoked brain damage is desirable. Melatonin, a sleep–wake-cycle-regulating neurohormone, exerts strong antioxidant and anti-inflammatory effects and is well tolerated when used as a drug. Due to these properties, it is very reasonable to consider melatonin as a potential therapeutic molecule for TBI treatment. This review summarizes data from in vitro studies, animal models, and clinical trials that focus on the usage of melatonin in TBI.https://www.mdpi.com/2076-3921/14/1/25melatonintraumatic brain injuryoxidative stressneuroinflammation |
| spellingShingle | Mariusz Sieminski Michalina Reimus Maria Kałas Ewelina Stępniewska Antioxidant and Anti-Inflammatory Properties of Melatonin in Secondary Traumatic Brain Injury Antioxidants melatonin traumatic brain injury oxidative stress neuroinflammation |
| title | Antioxidant and Anti-Inflammatory Properties of Melatonin in Secondary Traumatic Brain Injury |
| title_full | Antioxidant and Anti-Inflammatory Properties of Melatonin in Secondary Traumatic Brain Injury |
| title_fullStr | Antioxidant and Anti-Inflammatory Properties of Melatonin in Secondary Traumatic Brain Injury |
| title_full_unstemmed | Antioxidant and Anti-Inflammatory Properties of Melatonin in Secondary Traumatic Brain Injury |
| title_short | Antioxidant and Anti-Inflammatory Properties of Melatonin in Secondary Traumatic Brain Injury |
| title_sort | antioxidant and anti inflammatory properties of melatonin in secondary traumatic brain injury |
| topic | melatonin traumatic brain injury oxidative stress neuroinflammation |
| url | https://www.mdpi.com/2076-3921/14/1/25 |
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