17β-estradiol maintains extracellular matrix homeostasis of nucleus pulposus cells by activating p70 S6K1 signaling pathway

17β-estradiol maintains extracellular matrix homeostasis of nucleus pulposus cells by activating p70 S6K1 signaling pathway

BackgroundEstrogen can inhibit the apoptosis of nucleus pulposus cells (NPCs) through the PI3K/AKT/mTOR signaling pathway. However, the downstream of mTOR signaling pathway remains elusive. This study investigates the effect of 17β-estradiol (E2) on intervertebral disc degeneration (IVDD) through th...

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Bibliographic Details
Main Authors: Tao Liu, Zhaohui Li, Wei Zhang, Xuzhao Guo, Guobin Liu, Dalong Yang, Sidong Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
intervertebral disc degeneration
nucleus pulposus
estradiol
P70 S6K1
mTOR
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1564458/full
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