Peroxisome Proliferator-Activated Receptors and Acute Lung Injury
Peroxisome proliferator-activated receptors are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. PPARs regulate several metabolic pathways by binding to sequence-specific PPAR response elements in the promoter region of target genes, including lipid biosy...
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Format: | Article |
Language: | English |
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Wiley
2007-01-01
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Series: | PPAR Research |
Online Access: | http://dx.doi.org/10.1155/2007/63745 |
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author | Rosanna Di Paola Salvatore Cuzzocrea |
author_facet | Rosanna Di Paola Salvatore Cuzzocrea |
author_sort | Rosanna Di Paola |
collection | DOAJ |
description | Peroxisome proliferator-activated receptors are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. PPARs regulate several metabolic pathways by binding to sequence-specific PPAR response elements in the promoter region of target genes, including lipid biosynthesis and glucose metabolism. Recently, PPARs and their respective ligands have been implicated as regulators of cellular inflammatory and immune responses. These molecules are thought to exert anti-inflammatory effects by negatively regulating the expression of proinflammatory genes. Several studies have demonstrated that PPAR ligands possess anti-inflammatory properties and that these properties may prove helpful in the treatment of inflammatory diseases of the lung. This review will outline the anti-inflammatory effects of PPARs and PPAR ligands and discuss their potential therapeutic effects in animal models of inflammatory lung disease. |
format | Article |
id | doaj-art-08d21aef68534c75b5e390077dd8ffc9 |
institution | Kabale University |
issn | 1687-4757 1687-4765 |
language | English |
publishDate | 2007-01-01 |
publisher | Wiley |
record_format | Article |
series | PPAR Research |
spelling | doaj-art-08d21aef68534c75b5e390077dd8ffc92025-02-03T01:13:02ZengWileyPPAR Research1687-47571687-47652007-01-01200710.1155/2007/6374563745Peroxisome Proliferator-Activated Receptors and Acute Lung InjuryRosanna Di Paola0Salvatore Cuzzocrea1Department of Clinical, Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Via C. Valeria, Torre Biologica, Policlinico Universitario, Messina 98123, ItalyDepartment of Clinical, Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Via C. Valeria, Torre Biologica, Policlinico Universitario, Messina 98123, ItalyPeroxisome proliferator-activated receptors are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. PPARs regulate several metabolic pathways by binding to sequence-specific PPAR response elements in the promoter region of target genes, including lipid biosynthesis and glucose metabolism. Recently, PPARs and their respective ligands have been implicated as regulators of cellular inflammatory and immune responses. These molecules are thought to exert anti-inflammatory effects by negatively regulating the expression of proinflammatory genes. Several studies have demonstrated that PPAR ligands possess anti-inflammatory properties and that these properties may prove helpful in the treatment of inflammatory diseases of the lung. This review will outline the anti-inflammatory effects of PPARs and PPAR ligands and discuss their potential therapeutic effects in animal models of inflammatory lung disease.http://dx.doi.org/10.1155/2007/63745 |
spellingShingle | Rosanna Di Paola Salvatore Cuzzocrea Peroxisome Proliferator-Activated Receptors and Acute Lung Injury PPAR Research |
title | Peroxisome Proliferator-Activated Receptors and Acute Lung Injury |
title_full | Peroxisome Proliferator-Activated Receptors and Acute Lung Injury |
title_fullStr | Peroxisome Proliferator-Activated Receptors and Acute Lung Injury |
title_full_unstemmed | Peroxisome Proliferator-Activated Receptors and Acute Lung Injury |
title_short | Peroxisome Proliferator-Activated Receptors and Acute Lung Injury |
title_sort | peroxisome proliferator activated receptors and acute lung injury |
url | http://dx.doi.org/10.1155/2007/63745 |
work_keys_str_mv | AT rosannadipaola peroxisomeproliferatoractivatedreceptorsandacutelunginjury AT salvatorecuzzocrea peroxisomeproliferatoractivatedreceptorsandacutelunginjury |