SORT1 promote the metastasis and invasion of hepatocellular carcinoma via p38/β-catenin/ZEB1 signaling pathway

Abstract Metastasis is the predominant reason for high mortality of hepatocellular carcinoma (HCC) patients. Understanding the molecular mechanisms underlying HCC metastases is critical. Here, we reported that SORT1 functioned as an oncogene by facilitating HCC metastasis. Elevated SORT1 expression...

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Bibliographic Details
Main Authors: Hongjie Chen, Wei Liao, Yuanhui Jiang, Guichan Liao, Xinrui Gao, Siyi Cen, Lili Liu, Jie Peng, Cai Shaohang
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07871-y
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