A higher order PUF complex is central to regulation of C. elegans germline stem cells

A higher order PUF complex is central to regulation of C. elegans germline stem cells

Abstract PUF RNA-binding proteins are broadly conserved stem cell regulators. Nematode PUF proteins maintain germline stem cells (GSCs) and, with key partner proteins, repress differentiation mRNAs, including gld-1. Here we report that PUF protein FBF-2 and its partner LST-1 form a ternary complex t...

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Main Authors: Chen Qiu, Sarah L. Crittenden, Brian H. Carrick, Lucas B. Dillard, Stephany J. Costa Dos Santos, Venkata P. Dandey, Robert C. Dutcher, Elizabeth G. Viverette, Robert N. Wine, Jennifer Woodworth, Zachary T. Campbell, Marvin Wickens, Mario J. Borgnia, Judith Kimble, Traci M. Tanaka Hall
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55526-x
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https://doi.org/10.1038/s41467-024-55526-x

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