Oligodendrocyte precursor cell-derived exosomes combined with cell therapy promote clinical recovery by immunomodulation and gliosis attenuation

Oligodendrocyte precursor cell-derived exosomes combined with cell therapy promote clinical recovery by immunomodulation and gliosis attenuation

Multiple sclerosis is a chronic inflammatory disease of the central nervous system characterized by autoimmune destruction of the myelin sheath, leading to irreversible and progressive functional deficits in patients. Pre-clinical studies involving the use of neural stem cells (NSCs) have already de...

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Main Authors: Sarah Ingrid Pinto Santos, Santiago José Ortiz-Peñuela, Alessandro de Paula Filho, Ana Laura Midori Rossi Tomiyama, Lilian de Oliveira Coser, Juliano Coelho da Silveira, Daniele dos Santos Martins, Adriano Polican Ciena, Alexandre Leite Rodrigues de Oliveira, Carlos Eduardo Ambrósio
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
extracellular vesicles
multiple sclerosis
neural stem cell
neurodegeneration
immunomodulation
oligodendrocyte precursor cell
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2024.1413843/full
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https://www.frontiersin.org/articles/10.3389/fncel.2024.1413843/full

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