Obesity Differentially Affects Phenotypes of Polycystic Ovary Syndrome
Obesity or overweight affect most of patients with polycystic ovary syndrome (PCOS). Phenotypes are the clinical characteristics produced by the interaction of heredity and environment in a disease or syndrome. Phenotypes of PCOS have been described on the presence of clinical hyperandrogenism, olig...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/317241 |
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| author | Carlos Moran Monica Arriaga Gustavo Rodriguez Segundo Moran |
| author_facet | Carlos Moran Monica Arriaga Gustavo Rodriguez Segundo Moran |
| author_sort | Carlos Moran |
| collection | DOAJ |
| description | Obesity or overweight affect most of patients with polycystic ovary syndrome (PCOS). Phenotypes are the clinical characteristics produced by the interaction of heredity and environment in a disease or syndrome. Phenotypes of PCOS have been described on the presence of clinical hyperandrogenism, oligoovulation and polycystic ovaries. The insulin resistance is present in the majority of patients with obesity and/or PCOS and it is more frequent and of greater magnitude in obese than in non obese PCOS patients. Levels of sexual hormone binding globulin are decreased, and levels of free androgens are increased in obese PCOS patients. Weight loss treatment is important for overweight or obese PCOS patients, but not necessary for normal weight PCOS patients, who only need to avoid increasing their body weight. Obesity decreases or delays several infertility treatments. The differences in the hormonal and metabolic profile, as well as the different focus and response to treatment between obese and non obese PCOS patients suggest that obesity has to be considered as a characteristic for classification of PCOS phenotypes. |
| format | Article |
| id | doaj-art-07a64c8f05c24aad8126905cb3c1e5c4 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-07a64c8f05c24aad8126905cb3c1e5c42025-02-03T01:31:38ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/317241317241Obesity Differentially Affects Phenotypes of Polycystic Ovary SyndromeCarlos Moran0Monica Arriaga1Gustavo Rodriguez2Segundo Moran3Direction of Health Research and Training, Medical Unit of High Specialty, Gynecology and Obstetrics Hospital No. 4 Luis Castelazo Ayala, Mexican Institute of Social Security, Mexico City, DF 01090, MexicoDirection of Health Research and Training, Medical Unit of High Specialty, Gynecology and Obstetrics Hospital No. 4 Luis Castelazo Ayala, Mexican Institute of Social Security, Mexico City, DF 01090, MexicoGeneral Hospital of Zone No. 8, Mexican Institute of Social Security, Mexico City, DF 01090, MexicoHealth Research Council, Mexican Institute of Social Security, Mexico City, DF 06725, MexicoObesity or overweight affect most of patients with polycystic ovary syndrome (PCOS). Phenotypes are the clinical characteristics produced by the interaction of heredity and environment in a disease or syndrome. Phenotypes of PCOS have been described on the presence of clinical hyperandrogenism, oligoovulation and polycystic ovaries. The insulin resistance is present in the majority of patients with obesity and/or PCOS and it is more frequent and of greater magnitude in obese than in non obese PCOS patients. Levels of sexual hormone binding globulin are decreased, and levels of free androgens are increased in obese PCOS patients. Weight loss treatment is important for overweight or obese PCOS patients, but not necessary for normal weight PCOS patients, who only need to avoid increasing their body weight. Obesity decreases or delays several infertility treatments. The differences in the hormonal and metabolic profile, as well as the different focus and response to treatment between obese and non obese PCOS patients suggest that obesity has to be considered as a characteristic for classification of PCOS phenotypes.http://dx.doi.org/10.1155/2012/317241 |
| spellingShingle | Carlos Moran Monica Arriaga Gustavo Rodriguez Segundo Moran Obesity Differentially Affects Phenotypes of Polycystic Ovary Syndrome International Journal of Endocrinology |
| title | Obesity Differentially Affects Phenotypes of Polycystic Ovary Syndrome |
| title_full | Obesity Differentially Affects Phenotypes of Polycystic Ovary Syndrome |
| title_fullStr | Obesity Differentially Affects Phenotypes of Polycystic Ovary Syndrome |
| title_full_unstemmed | Obesity Differentially Affects Phenotypes of Polycystic Ovary Syndrome |
| title_short | Obesity Differentially Affects Phenotypes of Polycystic Ovary Syndrome |
| title_sort | obesity differentially affects phenotypes of polycystic ovary syndrome |
| url | http://dx.doi.org/10.1155/2012/317241 |
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