Immunity in the Cervix: Interphase between Immune and Cervical Epithelial Cells
The cervix is divided into two morphologically and immunologically distinct regions, namely, (1) the microbe-laden ectocervix, which is proximal to the vagina, and (2) the “sterile” endocervix, which is distal to the uterus. The two cervical regions are bordered by the cervical transformation zone (...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/7693183 |
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| author | Jorgelina Barrios De Tomasi Michael Makokha Opata Chishimba Nathan Mowa |
| author_facet | Jorgelina Barrios De Tomasi Michael Makokha Opata Chishimba Nathan Mowa |
| author_sort | Jorgelina Barrios De Tomasi |
| collection | DOAJ |
| description | The cervix is divided into two morphologically and immunologically distinct regions, namely, (1) the microbe-laden ectocervix, which is proximal to the vagina, and (2) the “sterile” endocervix, which is distal to the uterus. The two cervical regions are bordered by the cervical transformation zone (CTZ), an area of changing cells, and are predominantly composed of cervical epithelial cells. Epithelial cells are known to play a crucial role in the initiation, maintenance, and regulation of innate and adaptive response in collaboration with immune cells in several tissue types, including the cervix, and their dysfunction can lead to a spectrum of clinical syndromes. For instance, epithelial cells block progression and neutralize or kill microorganisms through multiple ways. These (ways) include mounting physical (intercellular junctions, secretion of mucus) and immune barriers (pathogen-recognition receptor-mediated pathways), which collectively and ultimately lead to the release of specific chemokines and or cytokines. The cytokines subsequently recruit subsets of immune cells appropriate to a particular immune context and response, such as dendritic cells (DCs), T, B, and natural killer (NK) cells. The immune response, as most biological processes in the female reproductive tract (FRT), is mainly regulated by estrogen and progesterone and their (immune cells) responses vary during different physiological phases of reproduction, such as menstrual cycle, pregnancy, and post menopause. The purpose of the present review is to compare the immunological profile of the mucosae and immune cells in the ecto- and endocervix and their interphase during the different phases of female reproduction. |
| format | Article |
| id | doaj-art-078ef057fb9e41b9b29416363a1693bb |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
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| series | Journal of Immunology Research |
| spelling | doaj-art-078ef057fb9e41b9b29416363a1693bb2025-02-03T01:32:44ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/76931837693183Immunity in the Cervix: Interphase between Immune and Cervical Epithelial CellsJorgelina Barrios De Tomasi0Michael Makokha Opata1Chishimba Nathan Mowa2Department of Biology, Appalachian State University, Boone 28608, USADepartment of Biology, Appalachian State University, Boone 28608, USADepartment of Biology, Appalachian State University, Boone 28608, USAThe cervix is divided into two morphologically and immunologically distinct regions, namely, (1) the microbe-laden ectocervix, which is proximal to the vagina, and (2) the “sterile” endocervix, which is distal to the uterus. The two cervical regions are bordered by the cervical transformation zone (CTZ), an area of changing cells, and are predominantly composed of cervical epithelial cells. Epithelial cells are known to play a crucial role in the initiation, maintenance, and regulation of innate and adaptive response in collaboration with immune cells in several tissue types, including the cervix, and their dysfunction can lead to a spectrum of clinical syndromes. For instance, epithelial cells block progression and neutralize or kill microorganisms through multiple ways. These (ways) include mounting physical (intercellular junctions, secretion of mucus) and immune barriers (pathogen-recognition receptor-mediated pathways), which collectively and ultimately lead to the release of specific chemokines and or cytokines. The cytokines subsequently recruit subsets of immune cells appropriate to a particular immune context and response, such as dendritic cells (DCs), T, B, and natural killer (NK) cells. The immune response, as most biological processes in the female reproductive tract (FRT), is mainly regulated by estrogen and progesterone and their (immune cells) responses vary during different physiological phases of reproduction, such as menstrual cycle, pregnancy, and post menopause. The purpose of the present review is to compare the immunological profile of the mucosae and immune cells in the ecto- and endocervix and their interphase during the different phases of female reproduction.http://dx.doi.org/10.1155/2019/7693183 |
| spellingShingle | Jorgelina Barrios De Tomasi Michael Makokha Opata Chishimba Nathan Mowa Immunity in the Cervix: Interphase between Immune and Cervical Epithelial Cells Journal of Immunology Research |
| title | Immunity in the Cervix: Interphase between Immune and Cervical Epithelial Cells |
| title_full | Immunity in the Cervix: Interphase between Immune and Cervical Epithelial Cells |
| title_fullStr | Immunity in the Cervix: Interphase between Immune and Cervical Epithelial Cells |
| title_full_unstemmed | Immunity in the Cervix: Interphase between Immune and Cervical Epithelial Cells |
| title_short | Immunity in the Cervix: Interphase between Immune and Cervical Epithelial Cells |
| title_sort | immunity in the cervix interphase between immune and cervical epithelial cells |
| url | http://dx.doi.org/10.1155/2019/7693183 |
| work_keys_str_mv | AT jorgelinabarriosdetomasi immunityinthecervixinterphasebetweenimmuneandcervicalepithelialcells AT michaelmakokhaopata immunityinthecervixinterphasebetweenimmuneandcervicalepithelialcells AT chishimbanathanmowa immunityinthecervixinterphasebetweenimmuneandcervicalepithelialcells |