Impact of Transchalcone on Neurological Outcomes in Cerebral Ischemia-reperfusion Injury in Rat: Role of AMP-activated Protein Kinase-mitochondrial Signaling Pathways

Impact of Transchalcone on Neurological Outcomes in Cerebral Ischemia-reperfusion Injury in Rat: Role of AMP-activated Protein Kinase-mitochondrial Signaling Pathways

Cerebral ischemia-reperfusion (CIR) injury results in significant secondary brain damage after ischemic stroke due to oxidative stress, mitochondrial dysfunction, and neuroinflammation. Transchalcone (TCH), a polyphenolic compound, exhibits antioxidant and anti-inflammatory properties that may contr...

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Bibliographic Details
Main Authors:	Xiuyun Xue, Jingjing Du, Shaik Althaf Hussain, Narendra Maddu, Jing Xiong
Format:	Article
Language:	English
Published:	Wolters Kluwer Medknow Publications 2025-05-01
Series:	Journal of Physiological Investigation
Subjects:	amp-activated protein kinase cerebral ischemia mitochondrial function neuroinflammation neuroprotection transchalcone
Online Access:	https://journals.lww.com/jpi/fulltext/2025/05000/impact_of_transchalcone_on_neurological_outcomes.5.aspx
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