A reproducible framework for monitoring the impact of randomized clinical trials on clinical practice using large-scale real-world data: application to gynaecological surgical trials using the French national healthcare databaseResearch in context

A reproducible framework for monitoring the impact of randomized clinical trials on clinical practice using large-scale real-world data: application to gynaecological surgical trials using the French national healthcare databaseResearch in context

Summary: Background: Randomized clinical trials (RCTs) are fundamental to evidence-based medicine, but their real-world impact on clinical practice often remains unmonitored. Leveraging large-scale real-world data can enable systematic monitoring of RCT effects. We aimed to develop a reproducible f...

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Main Authors: Floriane Jochum, Madeleine Doll, Anne-Sophie Hamy, Lou Donval, Paul Gougis, Élise Dumas, Lise Lecointre, Thomas Gaillard, Fabien Reyal, Fabrice Lecuru, Cherif Akladios, Enora Laas
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:EClinicalMedicine
Subjects:
Randomized clinical trials
Evidence-based medicine
Monitoring
Real-world impact
Time series analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537024006321
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