Shedding Light on the Prognostic and Predictive Value of Circulating Tumor DNA for Management of Patients with Early-Stage Colon Cancer
The management of early-stage colon cancer involves surgical resection of the primary tumor with or without chemotherapy, depending on pathological staging. The benefit of adjuvant chemotherapy for stage II and III colon cancer is approximately 5% and 15%, indicating the need for optimization for ri...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-01-01
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| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/15330338251317094 |
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| author | Rami Yanes MD Turcin Saridogan MD, PhD Vikram Gorantla MD Abigail Overacre PhD Ronan W. Hsieh MD James Celebrezze MD Tara Magge MD Meghana Singhi MD Anwaar Saeed MD Amer H. Zureikat MD Arvind N. Dasari MD Ibrahim Halil Sahin MD |
| author_facet | Rami Yanes MD Turcin Saridogan MD, PhD Vikram Gorantla MD Abigail Overacre PhD Ronan W. Hsieh MD James Celebrezze MD Tara Magge MD Meghana Singhi MD Anwaar Saeed MD Amer H. Zureikat MD Arvind N. Dasari MD Ibrahim Halil Sahin MD |
| author_sort | Rami Yanes MD |
| collection | DOAJ |
| description | The management of early-stage colon cancer involves surgical resection of the primary tumor with or without chemotherapy, depending on pathological staging. The benefit of adjuvant chemotherapy for stage II and III colon cancer is approximately 5% and 15%, indicating the need for optimization for risk stratification and patient selection. Several studies have revealed that current clinicopathological factors lack precision. Circulating tumor DNA (ctDNA) is cell-free DNA originating from cancer cells and can be detected even in the absence of radiologically detectable disease among patients with colon cancer. Recent cohort studies revealed that ctDNA is one of the most significant prognostic factors for patients with early-stage colon cancer, surpassing pathological and clinical risk factors. Prospective cohort studies also suggest there may be a predictive role for ctDNA on the decision for consideration of adjuvant therapy. Currently, randomized clinical trials are enrolling to better define this role. In this review article, we review recent literature on ctDNA and its role in patients with colon cancer. We also elaborate on the future clinical utility of ctDNA in clinical practice and the unmet need for research to optimize currently available ctDNA assays. |
| format | Article |
| id | doaj-art-0711617c324c40f489bee94814870664 |
| institution | Kabale University |
| issn | 1533-0338 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj-art-0711617c324c40f489bee948148706642025-01-27T13:03:33ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382025-01-012410.1177/15330338251317094Shedding Light on the Prognostic and Predictive Value of Circulating Tumor DNA for Management of Patients with Early-Stage Colon CancerRami Yanes MD0Turcin Saridogan MD, PhD1Vikram Gorantla MD2Abigail Overacre PhD3Ronan W. Hsieh MD4James Celebrezze MD5Tara Magge MD6Meghana Singhi MD7Anwaar Saeed MD8Amer H. Zureikat MD9Arvind N. Dasari MD10Ibrahim Halil Sahin MD11 Division of Hematology/Oncology, , Pittsburgh, PA, USA Hacettepe University School of Medicine, Turkey Division of Hematology/Oncology, , Pittsburgh, PA, USA Department of Immunology, Tumor Microenvironment Center UPMC Hillman Cancer Center, USA , University of Washington, USA Department of Surgery, , USA Division of Hematology/Oncology, , Pittsburgh, PA, USA Division of Hematology/Oncology, , Pittsburgh, PA, USA Division of Hematology/Oncology, , Pittsburgh, PA, USA Department of Surgery, , USA Department of Gastrointestinal Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Division of Hematology/Oncology, , Pittsburgh, PA, USAThe management of early-stage colon cancer involves surgical resection of the primary tumor with or without chemotherapy, depending on pathological staging. The benefit of adjuvant chemotherapy for stage II and III colon cancer is approximately 5% and 15%, indicating the need for optimization for risk stratification and patient selection. Several studies have revealed that current clinicopathological factors lack precision. Circulating tumor DNA (ctDNA) is cell-free DNA originating from cancer cells and can be detected even in the absence of radiologically detectable disease among patients with colon cancer. Recent cohort studies revealed that ctDNA is one of the most significant prognostic factors for patients with early-stage colon cancer, surpassing pathological and clinical risk factors. Prospective cohort studies also suggest there may be a predictive role for ctDNA on the decision for consideration of adjuvant therapy. Currently, randomized clinical trials are enrolling to better define this role. In this review article, we review recent literature on ctDNA and its role in patients with colon cancer. We also elaborate on the future clinical utility of ctDNA in clinical practice and the unmet need for research to optimize currently available ctDNA assays.https://doi.org/10.1177/15330338251317094 |
| spellingShingle | Rami Yanes MD Turcin Saridogan MD, PhD Vikram Gorantla MD Abigail Overacre PhD Ronan W. Hsieh MD James Celebrezze MD Tara Magge MD Meghana Singhi MD Anwaar Saeed MD Amer H. Zureikat MD Arvind N. Dasari MD Ibrahim Halil Sahin MD Shedding Light on the Prognostic and Predictive Value of Circulating Tumor DNA for Management of Patients with Early-Stage Colon Cancer Technology in Cancer Research & Treatment |
| title | Shedding Light on the Prognostic and Predictive Value of Circulating Tumor
DNA for Management of Patients with
Early-Stage Colon Cancer |
| title_full | Shedding Light on the Prognostic and Predictive Value of Circulating Tumor
DNA for Management of Patients with
Early-Stage Colon Cancer |
| title_fullStr | Shedding Light on the Prognostic and Predictive Value of Circulating Tumor
DNA for Management of Patients with
Early-Stage Colon Cancer |
| title_full_unstemmed | Shedding Light on the Prognostic and Predictive Value of Circulating Tumor
DNA for Management of Patients with
Early-Stage Colon Cancer |
| title_short | Shedding Light on the Prognostic and Predictive Value of Circulating Tumor
DNA for Management of Patients with
Early-Stage Colon Cancer |
| title_sort | shedding light on the prognostic and predictive value of circulating tumor dna for management of patients with early stage colon cancer |
| url | https://doi.org/10.1177/15330338251317094 |
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