When the most potent combination of antibiotics selects for the greatest bacterial load: the smile-frown transition.

Conventional wisdom holds that the best way to treat infection with antibiotics is to 'hit early and hit hard'. A favoured strategy is to deploy two antibiotics that produce a stronger effect in combination than if either drug were used alone. But are such synergistic combinations necessar...

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Bibliographic Details
Main Authors: Rafael Pena-Miller, David Laehnemann, Gunther Jansen, Ayari Fuentes-Hernandez, Philip Rosenstiel, Hinrich Schulenburg, Robert Beardmore
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1001540&type=printable
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