Beyond traditional metrics: evaluating the triglyceride-total cholesterol-body weight index (TCBI) in cardiovascular risk assessment
Abstract Background Cardiovascular disease (CVD), a non-communicable condition, stands as the primary cause of death globally. This study seeks to evaluate the predictive power of atherogenic indices, which are recognized for their influence on CVD, alongside a newly developed index encompassing all...
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| Language: | English |
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BMC
2025-01-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-025-04500-6 |
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| author | Mohsen Rezaee Farzam Kamrani Mobina Imannezhad Hamed Hashemi Shahri Waleed Khaled Saihood Alireza Rezvani Parsa Mearaji Far Hanie Mahaki Habibollah Esmaily Mohsen Moohebati Mohammad Shariati Majid Ghayour-Mobarhan Susan Darroudi |
| author_facet | Mohsen Rezaee Farzam Kamrani Mobina Imannezhad Hamed Hashemi Shahri Waleed Khaled Saihood Alireza Rezvani Parsa Mearaji Far Hanie Mahaki Habibollah Esmaily Mohsen Moohebati Mohammad Shariati Majid Ghayour-Mobarhan Susan Darroudi |
| author_sort | Mohsen Rezaee |
| collection | DOAJ |
| description | Abstract Background Cardiovascular disease (CVD), a non-communicable condition, stands as the primary cause of death globally. This study seeks to evaluate the predictive power of atherogenic indices, which are recognized for their influence on CVD, alongside a newly developed index encompassing all three principal risk factors for CVD, referred to as the triglyceride-total cholesterol-body weight index (TCBI). The primary outcomes evaluated include both the incidence and mortality rates associated with CVD. Methods A prospective cohort study was conducted on Mashhad stroke and heart atherosclerotic disorder (MASHAD) study data, involving 9704 healthy participants. Baseline variables were measured, and TCBI, Atherogenic Index of Plasma (AIP), Atherogenic Coefficient (AC), Castelli risk index I and II (CRI-I & II) were calculated using specific formulas. Results Following a 10-year follow-up period, a significant positive relationship was observed between TCBI (HR: 1.078, 95% CI: 1.012–1.15), CRI-I (HR: 1.16, 95% CI: 1.007–1.337), and CRI-II (HR: 1.199, 95% CI: 1.001–1.437) with CVD mortality. However, no significant relationship was identified between TCBI and atherogenic indices related to CVD incidence, and neither AIP nor AC was associated with CVD mortality. Conclusion In conclusion, TCBI, in contrast to AC and AIP, was linked to increased CVD mortality. However, the more substantial predictive capabilities of CRI-I and CRI-II compared to TCBI emphasize the importance of traditional atherogenic indices for accurate risk assessment. These findings underscore the necessity of enhancing the TCBI formula to improve its effectiveness in assessing CVD risk. |
| format | Article |
| id | doaj-art-06f5604288bf46aba1b1a3616b9c8fe9 |
| institution | Kabale University |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-06f5604288bf46aba1b1a3616b9c8fe92025-01-26T12:14:21ZengBMCBMC Cardiovascular Disorders1471-22612025-01-012511810.1186/s12872-025-04500-6Beyond traditional metrics: evaluating the triglyceride-total cholesterol-body weight index (TCBI) in cardiovascular risk assessmentMohsen Rezaee0Farzam Kamrani1Mobina Imannezhad2Hamed Hashemi Shahri3Waleed Khaled Saihood4Alireza Rezvani5Parsa Mearaji Far6Hanie Mahaki7Habibollah Esmaily8Mohsen Moohebati9Mohammad Shariati10Majid Ghayour-Mobarhan11Susan Darroudi12Student Research Committee, School of Medicine, Semnan University of Medical SciencesDepartment of Nutrition, Faculty of Medicine, Mashhad University of Medical SciencesDepartment of Nutrition, Faculty of Medicine, Mashhad University of Medical SciencesDepartment of Clinical Pharmacy, Damghan Branch, Islamic Azad UniversityDepartment of Biochemistry and Biophysics, Faculty of Sciences, Mashhad Branch, Islamic Azad UniversityMetabolic syndrome Research Center, School of Medicine, Mashhad University of Medical SciencesMetabolic syndrome Research Center, School of Medicine, Mashhad University of Medical SciencesMetabolic syndrome Research Center, School of Medicine, Mashhad University of Medical SciencesDepartment of Biostatistics, School of Health, Mashhad University of Medical SciencesMetabolic syndrome Research Center, School of Medicine, Mashhad University of Medical SciencesBlood Burn Infections Research Center, Academic Center for Education, Culture and Research (ACECR, Vascular and Endovascular Surgery Research Center, Mashhad University of medical sciencesMetabolic syndrome Research Center, School of Medicine, Mashhad University of Medical SciencesVascular and Endovascular Surgery Research Center, Mashhad University of medical sciencesAbstract Background Cardiovascular disease (CVD), a non-communicable condition, stands as the primary cause of death globally. This study seeks to evaluate the predictive power of atherogenic indices, which are recognized for their influence on CVD, alongside a newly developed index encompassing all three principal risk factors for CVD, referred to as the triglyceride-total cholesterol-body weight index (TCBI). The primary outcomes evaluated include both the incidence and mortality rates associated with CVD. Methods A prospective cohort study was conducted on Mashhad stroke and heart atherosclerotic disorder (MASHAD) study data, involving 9704 healthy participants. Baseline variables were measured, and TCBI, Atherogenic Index of Plasma (AIP), Atherogenic Coefficient (AC), Castelli risk index I and II (CRI-I & II) were calculated using specific formulas. Results Following a 10-year follow-up period, a significant positive relationship was observed between TCBI (HR: 1.078, 95% CI: 1.012–1.15), CRI-I (HR: 1.16, 95% CI: 1.007–1.337), and CRI-II (HR: 1.199, 95% CI: 1.001–1.437) with CVD mortality. However, no significant relationship was identified between TCBI and atherogenic indices related to CVD incidence, and neither AIP nor AC was associated with CVD mortality. Conclusion In conclusion, TCBI, in contrast to AC and AIP, was linked to increased CVD mortality. However, the more substantial predictive capabilities of CRI-I and CRI-II compared to TCBI emphasize the importance of traditional atherogenic indices for accurate risk assessment. These findings underscore the necessity of enhancing the TCBI formula to improve its effectiveness in assessing CVD risk.https://doi.org/10.1186/s12872-025-04500-6CVDMortalityTCBIAtherogenic indicesACCRI-I |
| spellingShingle | Mohsen Rezaee Farzam Kamrani Mobina Imannezhad Hamed Hashemi Shahri Waleed Khaled Saihood Alireza Rezvani Parsa Mearaji Far Hanie Mahaki Habibollah Esmaily Mohsen Moohebati Mohammad Shariati Majid Ghayour-Mobarhan Susan Darroudi Beyond traditional metrics: evaluating the triglyceride-total cholesterol-body weight index (TCBI) in cardiovascular risk assessment BMC Cardiovascular Disorders CVD Mortality TCBI Atherogenic indices AC CRI-I |
| title | Beyond traditional metrics: evaluating the triglyceride-total cholesterol-body weight index (TCBI) in cardiovascular risk assessment |
| title_full | Beyond traditional metrics: evaluating the triglyceride-total cholesterol-body weight index (TCBI) in cardiovascular risk assessment |
| title_fullStr | Beyond traditional metrics: evaluating the triglyceride-total cholesterol-body weight index (TCBI) in cardiovascular risk assessment |
| title_full_unstemmed | Beyond traditional metrics: evaluating the triglyceride-total cholesterol-body weight index (TCBI) in cardiovascular risk assessment |
| title_short | Beyond traditional metrics: evaluating the triglyceride-total cholesterol-body weight index (TCBI) in cardiovascular risk assessment |
| title_sort | beyond traditional metrics evaluating the triglyceride total cholesterol body weight index tcbi in cardiovascular risk assessment |
| topic | CVD Mortality TCBI Atherogenic indices AC CRI-I |
| url | https://doi.org/10.1186/s12872-025-04500-6 |
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