Evaluation of Non-cross-linked Hyaluronic Acid on Oral Wound Healing After Diode Laser and Scalpel Incisions
Background:. The aim was to assess the impact of non-cross-linked hyaluronic acid (HA) injections on the healing of intraoral wounds from 3 types of incisions. Methods:. A total of 36 Wister albino rats were included in this research. The rats were randomly assigned to 1 of 6 groups: the first group...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2025-05-01
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| Series: | Plastic and Reconstructive Surgery, Global Open |
| Online Access: | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000006836 |
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| Summary: | Background:. The aim was to assess the impact of non-cross-linked hyaluronic acid (HA) injections on the healing of intraoral wounds from 3 types of incisions.
Methods:. A total of 36 Wister albino rats were included in this research. The rats were randomly assigned to 1 of 6 groups: the first group underwent a scalpel incision in the buccal mucosa with HA injection. The second group received a laser incision using a 976-nm diode laser with HA injection, whereas the third group was subjected to a laser incision with a 450-nm diode laser with HA injection. The fourth group underwent scalpel incision only, the fifth group received a 976-nm laser incision only, and the sixth group received a 450-nm laser incision only. Biopsies were collected at baseline, as well as on the third and seventh days, to assess wound healing using hematoxylin and eosin and Masson trichrome staining.
Results:. Group 3 exhibited the most pronounced results on the third and seventh days after surgery, with collagen formation noted alongside well-organized granulation tissue that contributed to improved and expedited wound healing.
Conclusions:. In this low-volume experimental study, HA injections in wounds made with a 450-nm diode laser demonstrated encouraging outcomes, enhancing the healing process and resulting in quicker recovery. |
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| ISSN: | 2169-7574 |