Role of spindle assembly checkpoint proteins in gametogenesis and embryogenesis
The spindle assembly checkpoint (SAC) is a surveillance mechanism that prevents uneven segregation of sister chromatids between daughter cells during anaphase. This essential regulatory checkpoint prevents aneuploidy which can lead to various congenital defects observed in newborns. Many studies hav...
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| Format: | Article |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1491394/full |
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| author | Renju Pun Brian J. North |
| author_facet | Renju Pun Brian J. North |
| author_sort | Renju Pun |
| collection | DOAJ |
| description | The spindle assembly checkpoint (SAC) is a surveillance mechanism that prevents uneven segregation of sister chromatids between daughter cells during anaphase. This essential regulatory checkpoint prevents aneuploidy which can lead to various congenital defects observed in newborns. Many studies have been carried out to elucidate the role of proteins involved in the SAC as well as the function of the checkpoint during gametogenesis and embryogenesis. In this review, we discuss the role of SAC proteins in regulating both meiotic and mitotic cell division along with several factors that influence the SAC strength in various species. Finally, we outline the role of SAC proteins and the consequences of their absence or insufficiency on proper gametogenesis and embryogenesis in vivo. |
| format | Article |
| id | doaj-art-06c443d2357e471e9a7c0cbeb3fe4af2 |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-06c443d2357e471e9a7c0cbeb3fe4af22025-01-22T07:13:51ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-01-011210.3389/fcell.2024.14913941491394Role of spindle assembly checkpoint proteins in gametogenesis and embryogenesisRenju PunBrian J. NorthThe spindle assembly checkpoint (SAC) is a surveillance mechanism that prevents uneven segregation of sister chromatids between daughter cells during anaphase. This essential regulatory checkpoint prevents aneuploidy which can lead to various congenital defects observed in newborns. Many studies have been carried out to elucidate the role of proteins involved in the SAC as well as the function of the checkpoint during gametogenesis and embryogenesis. In this review, we discuss the role of SAC proteins in regulating both meiotic and mitotic cell division along with several factors that influence the SAC strength in various species. Finally, we outline the role of SAC proteins and the consequences of their absence or insufficiency on proper gametogenesis and embryogenesis in vivo.https://www.frontiersin.org/articles/10.3389/fcell.2024.1491394/fullspindle assembly checkpointembryogenesisgametogenesismitotic checkpointmitosis |
| spellingShingle | Renju Pun Brian J. North Role of spindle assembly checkpoint proteins in gametogenesis and embryogenesis Frontiers in Cell and Developmental Biology spindle assembly checkpoint embryogenesis gametogenesis mitotic checkpoint mitosis |
| title | Role of spindle assembly checkpoint proteins in gametogenesis and embryogenesis |
| title_full | Role of spindle assembly checkpoint proteins in gametogenesis and embryogenesis |
| title_fullStr | Role of spindle assembly checkpoint proteins in gametogenesis and embryogenesis |
| title_full_unstemmed | Role of spindle assembly checkpoint proteins in gametogenesis and embryogenesis |
| title_short | Role of spindle assembly checkpoint proteins in gametogenesis and embryogenesis |
| title_sort | role of spindle assembly checkpoint proteins in gametogenesis and embryogenesis |
| topic | spindle assembly checkpoint embryogenesis gametogenesis mitotic checkpoint mitosis |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1491394/full |
| work_keys_str_mv | AT renjupun roleofspindleassemblycheckpointproteinsingametogenesisandembryogenesis AT brianjnorth roleofspindleassemblycheckpointproteinsingametogenesisandembryogenesis |