Effective cancer immunotherapy combining mRNA-encoded bispecific antibodies that induce polyclonal T cell engagement and PD-L1-dependent 4-1BB costimulation

Effective cancer immunotherapy combining mRNA-encoded bispecific antibodies that induce polyclonal T cell engagement and PD-L1-dependent 4-1BB costimulation

BackgroundImmune checkpoint inhibitors have revolutionized cancer therapy, but many patients fail to respond or develop resistance, often due to reduced T cell activity. Costimulation via 4-1BB has emerged as a promising approach to enhance the effector function of antigen-primed T cells. Bispecific...

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Bibliographic Details
Main Authors: Oana Hangiu, Rocío Navarro, Susana Frago, Laura Rubio-Pérez, Antonio Tapia-Galisteo, Laura Díez-Alonso, Marina Gómez-Rosel, Noelia Silva-Pilipich, Lucía Vanrell, Cristian Smerdou, Kenneth A. Howard, Laura Sanz, Luis Álvarez-Vallina, Marta Compte
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
T-cell engager
costimulatory antibody
cancer immunotherapy
mRNA encoded bispecific antibodies
combined RNA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1494206/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1494206/full

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