Apigenin inhibits NLRP3 inflammasome activation in monocytes and macrophages independently of CD38

Apigenin inhibits NLRP3 inflammasome activation in monocytes and macrophages independently of CD38

IntroductionCD38, a regulator of intracellular calcium signalling, is highly expressed in immune cells. Mice lacking CD38 are very susceptible to acute bacterial infections, implicating CD38 in innate immune responses. The effects of CD38 inhibition on NLRP3 inflammasome activation in human primary...

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Main Authors: Knut Husø Lauritzen, Kuan Yang, Michael Frisk, Mieke C. Louwe, Maria Belland Olsen, Mathias Ziegler, William E. Louch, Bente Halvorsen, Pål Aukrust, Arne Yndestad, Øystein Sandanger
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
NLRP3
CD38
apigenin
inflammasome
monocyte
macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1497984/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1497984/full

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