Resveratrol liposomes reverse sorafenib resistance in renal cell carcinoma models by modulating PI3K-AKT-mTOR and VHL-HIF signaling pathways

Resveratrol liposomes reverse sorafenib resistance in renal cell carcinoma models by modulating PI3K-AKT-mTOR and VHL-HIF signaling pathways

RCC is a malignant tumor arising from the urothelium of renal parenchyma that remains challenging to be treated. In this study, we assessed the anti-tumor effects of Resveratrol liposomes (RES-lips) combined with sorafenib on renal cell carcinoma (RCC) and explored the potential mechanisms underlyin...

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Bibliographic Details
Main Authors: Ligang Wang, Ying Wang, Qiqi Xie, Songcheng Xu, Chen Yang, Fei Liu, Yang Liu, Fuwei Wang, Weinan Chen, Jianchun Li, Litao Sun
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
Resveratrol liposomes
Sorafenib
Resistance
Combination
Renal cell carcinoma
PI3K-AKT-mTOR
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156724000525
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http://www.sciencedirect.com/science/article/pii/S2590156724000525

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