Platelet-derived microparticles adoptively transfer integrin β3 to promote antitumor effect of tumor-infiltrating T cells

Platelet-derived microparticles adoptively transfer integrin β3 to promote antitumor effect of tumor-infiltrating T cells

Approximately two-thirds of hepatocellular carcinoma (HCC) is considered a “cold tumor” characterized by few tumor-infiltrating T cells and an abundance of immunosuppressive cells. Cilengitide, an integrin αvβ3 inhibitor, has failed in clinical trials as a potential anticancer drug. This failure imp...

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Bibliographic Details
Main Authors: Mimi Zhou, Yali Feng, Xiaoli Zhang, Jianguo Chen, Naijuan Yao, Shan Fu, Tianzhi Ni, Yi Chen, Fei Xie, Sahasrabda Roy, Jinfeng Liu, Yuan Yang, Yingli He, Yingren Zhao, Nan Yang
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:OncoImmunology
Subjects:
Hepatocellular carcinoma
integrin αvβ3
platelet-derived microparticles
tumor-infiltrating lymphocytes
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2024.2304963
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https://www.tandfonline.com/doi/10.1080/2162402X.2024.2304963

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