Anticancer Role of PPARγ Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes
The use of targeted cancer therapies in combination with conventional chemotherapeutic agents and/or radiation treatment has increased overall survival of cancer patients. However, longer survival is accompanied by increased incidence of comorbidities due, in part, to drug side effects and toxiciti...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2010/814609 |
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| author | P. J. Simpson-Haidaris S. J. Pollock S. Ramon N. Guo C. F. Woeller S. E. Feldon R. P. Phipps |
| author_facet | P. J. Simpson-Haidaris S. J. Pollock S. Ramon N. Guo C. F. Woeller S. E. Feldon R. P. Phipps |
| author_sort | P. J. Simpson-Haidaris |
| collection | DOAJ |
| description | The use of targeted cancer therapies in combination with conventional chemotherapeutic agents and/or radiation treatment has increased overall survival of cancer patients. However, longer survival is accompanied by increased incidence of comorbidities due, in part, to drug side effects and toxicities. It is well accepted that inflammation and tumorigenesis are linked. Because peroxisome proliferator-activated receptor (PPAR)-γ agonists are potent mediators of anti-inflammatory responses, it was a logical extension to examine the role of PPARγ agonists in the treatment and prevention of cancer. This paper has two objectives: first to highlight the potential uses for PPARγ agonists in anticancer therapy with special emphasis on their role when used as adjuvant or combined therapy in the treatment of hematological malignancies found in the vasculature, marrow, and eyes, and second, to review the potential role PPARγ and/or its ligands may have in modulating cancer-associated angiogenesis and tumor-stromal microenvironment crosstalk in bone marrow. |
| format | Article |
| id | doaj-art-06563ff9dd2c427bb6d386cbda16f3d0 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-06563ff9dd2c427bb6d386cbda16f3d02025-02-03T01:07:44ZengWileyPPAR Research1687-47571687-47652010-01-01201010.1155/2010/814609814609Anticancer Role of PPARγ Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and EyesP. J. Simpson-Haidaris0S. J. Pollock1S. Ramon2N. Guo3C. F. Woeller4S. E. Feldon5R. P. Phipps6Department of Medicine/Hem-Onc Division, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USADepartment of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USADepartment of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USADepartment of Opthalmology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USADepartment of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USADepartment of Opthalmology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USADepartment of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USAThe use of targeted cancer therapies in combination with conventional chemotherapeutic agents and/or radiation treatment has increased overall survival of cancer patients. However, longer survival is accompanied by increased incidence of comorbidities due, in part, to drug side effects and toxicities. It is well accepted that inflammation and tumorigenesis are linked. Because peroxisome proliferator-activated receptor (PPAR)-γ agonists are potent mediators of anti-inflammatory responses, it was a logical extension to examine the role of PPARγ agonists in the treatment and prevention of cancer. This paper has two objectives: first to highlight the potential uses for PPARγ agonists in anticancer therapy with special emphasis on their role when used as adjuvant or combined therapy in the treatment of hematological malignancies found in the vasculature, marrow, and eyes, and second, to review the potential role PPARγ and/or its ligands may have in modulating cancer-associated angiogenesis and tumor-stromal microenvironment crosstalk in bone marrow.http://dx.doi.org/10.1155/2010/814609 |
| spellingShingle | P. J. Simpson-Haidaris S. J. Pollock S. Ramon N. Guo C. F. Woeller S. E. Feldon R. P. Phipps Anticancer Role of PPARγ Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes PPAR Research |
| title | Anticancer Role of PPARγ Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes |
| title_full | Anticancer Role of PPARγ Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes |
| title_fullStr | Anticancer Role of PPARγ Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes |
| title_full_unstemmed | Anticancer Role of PPARγ Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes |
| title_short | Anticancer Role of PPARγ Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes |
| title_sort | anticancer role of pparγ agonists in hematological malignancies found in the vasculature marrow and eyes |
| url | http://dx.doi.org/10.1155/2010/814609 |
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