Glibenclamide targets MDH2 to relieve aging phenotypes through metabolism-regulated epigenetic modification

Glibenclamide targets MDH2 to relieve aging phenotypes through metabolism-regulated epigenetic modification

Abstract Mitochondrial metabolism-regulated epigenetic modification is a driving force of aging and a promising target for therapeutic intervention. Mitochondrial malate dehydrogenase (MDH2), an enzyme in the TCA cycle, was identified as an anti-aging target through activity-based protein profiling...

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Main Authors: Zhifan Mao, Wenwen Liu, Rong Zou, Ling Sun, Shuman Huang, Lingyu Wu, Liru Chen, Jiale Wu, Shijie Lu, Zhouzhi Song, Xie Li, Yunyuan Huang, Yong Rao, Yi-You Huang, Baoli Li, Zelan Hu, Jian Li
Format: Article
Language:English
Published: Nature Publishing Group 2025-02-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02157-3
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https://doi.org/10.1038/s41392-025-02157-3

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