High Prevalence of Autoimmune Diabetes and Poor Glycaemic Control among Adults in Madagascar: A Brief Report from a Humanitarian Health Campaign in Ambanja
Madagascar is a geographically isolated country considered a biodiversity hotspot with unique genomics. Both the low-income and the geographical isolation represent risk factors for the development of diabetes. During a humanitarian health campaign conducted in Ambanja, a rural city in the northern...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/3860674 |
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| author | Ernesto Maddaloni Giovanlorenzo Pastore Marco Giuseppe Del Buono Aldostefano Porcari Mario Fittipaldi Francesco Garilli Claudio Tiberti Silvia Angeletti Paolo Pozzilli Giovanni Mottini Nicola Napoli |
| author_facet | Ernesto Maddaloni Giovanlorenzo Pastore Marco Giuseppe Del Buono Aldostefano Porcari Mario Fittipaldi Francesco Garilli Claudio Tiberti Silvia Angeletti Paolo Pozzilli Giovanni Mottini Nicola Napoli |
| author_sort | Ernesto Maddaloni |
| collection | DOAJ |
| description | Madagascar is a geographically isolated country considered a biodiversity hotspot with unique genomics. Both the low-income and the geographical isolation represent risk factors for the development of diabetes. During a humanitarian health campaign conducted in Ambanja, a rural city in the northern part of Madagascar, we identified 42 adult subjects with diabetes and compared their features to 24 randomly enrolled healthy controls. 42.9% (n=18) of diabetic subjects showed HbA1c values ≥ 9.0%. Unexpectedly, waist circumference and BMI were similar in people with diabetes and controls. Different from the healthy controls, diabetic subjects showed a low prevalence of obesity (5.7% versus 30%, p=0.02). Accordingly, we found a high prevalence of autoimmune diabetes as 12% of people with diabetes showed positivity for the autoantibody against glutamic acid decarboxylase. Diabetic subjects with positive autoantibody had higher HbA1c values (11.3 ± 4.1% versus 8.3 ± 2.6%, p=0.03) compared to diabetic subjects with negative autoantibody. In conclusion, here we describe the presence of diabetes and its features in a rural area of Northern Madagascar, documenting poor glycaemic control and a high prevalence of autoimmune diabetes. These data highlight that the diabetes epidemic involves every corner of the world possibly with different patterns and features. |
| format | Article |
| id | doaj-art-063f4b5a791f4ff28ca037beabf24ceb |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-063f4b5a791f4ff28ca037beabf24ceb2025-02-03T05:52:18ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/38606743860674High Prevalence of Autoimmune Diabetes and Poor Glycaemic Control among Adults in Madagascar: A Brief Report from a Humanitarian Health Campaign in AmbanjaErnesto Maddaloni0Giovanlorenzo Pastore1Marco Giuseppe Del Buono2Aldostefano Porcari3Mario Fittipaldi4Francesco Garilli5Claudio Tiberti6Silvia Angeletti7Paolo Pozzilli8Giovanni Mottini9Nicola Napoli10Department of Medicine, Unit of Endocrinology, University Campus Bio-Medico, Rome, ItalyDepartment of Medicine, Unit of Endocrinology, University Campus Bio-Medico, Rome, ItalyDepartment of Medicine, Unit of Endocrinology, University Campus Bio-Medico, Rome, ItalyDepartment of Medicine, Unit of Endocrinology, University Campus Bio-Medico, Rome, ItalyDepartment of Medicine, Unit of Endocrinology, University Campus Bio-Medico, Rome, ItalyDepartment of Medicine, Unit of Endocrinology, University Campus Bio-Medico, Rome, ItalyDepartment of Medicine, Unit of Endocrinology, University Campus Bio-Medico, Rome, ItalyDepartment of Medicine, Unit of Endocrinology, University Campus Bio-Medico, Rome, ItalyDepartment of Medicine, Unit of Endocrinology, University Campus Bio-Medico, Rome, ItalyDepartment of Medicine, Unit of Endocrinology, University Campus Bio-Medico, Rome, ItalyDepartment of Medicine, Unit of Endocrinology, University Campus Bio-Medico, Rome, ItalyMadagascar is a geographically isolated country considered a biodiversity hotspot with unique genomics. Both the low-income and the geographical isolation represent risk factors for the development of diabetes. During a humanitarian health campaign conducted in Ambanja, a rural city in the northern part of Madagascar, we identified 42 adult subjects with diabetes and compared their features to 24 randomly enrolled healthy controls. 42.9% (n=18) of diabetic subjects showed HbA1c values ≥ 9.0%. Unexpectedly, waist circumference and BMI were similar in people with diabetes and controls. Different from the healthy controls, diabetic subjects showed a low prevalence of obesity (5.7% versus 30%, p=0.02). Accordingly, we found a high prevalence of autoimmune diabetes as 12% of people with diabetes showed positivity for the autoantibody against glutamic acid decarboxylase. Diabetic subjects with positive autoantibody had higher HbA1c values (11.3 ± 4.1% versus 8.3 ± 2.6%, p=0.03) compared to diabetic subjects with negative autoantibody. In conclusion, here we describe the presence of diabetes and its features in a rural area of Northern Madagascar, documenting poor glycaemic control and a high prevalence of autoimmune diabetes. These data highlight that the diabetes epidemic involves every corner of the world possibly with different patterns and features.http://dx.doi.org/10.1155/2017/3860674 |
| spellingShingle | Ernesto Maddaloni Giovanlorenzo Pastore Marco Giuseppe Del Buono Aldostefano Porcari Mario Fittipaldi Francesco Garilli Claudio Tiberti Silvia Angeletti Paolo Pozzilli Giovanni Mottini Nicola Napoli High Prevalence of Autoimmune Diabetes and Poor Glycaemic Control among Adults in Madagascar: A Brief Report from a Humanitarian Health Campaign in Ambanja Journal of Diabetes Research |
| title | High Prevalence of Autoimmune Diabetes and Poor Glycaemic Control among Adults in Madagascar: A Brief Report from a Humanitarian Health Campaign in Ambanja |
| title_full | High Prevalence of Autoimmune Diabetes and Poor Glycaemic Control among Adults in Madagascar: A Brief Report from a Humanitarian Health Campaign in Ambanja |
| title_fullStr | High Prevalence of Autoimmune Diabetes and Poor Glycaemic Control among Adults in Madagascar: A Brief Report from a Humanitarian Health Campaign in Ambanja |
| title_full_unstemmed | High Prevalence of Autoimmune Diabetes and Poor Glycaemic Control among Adults in Madagascar: A Brief Report from a Humanitarian Health Campaign in Ambanja |
| title_short | High Prevalence of Autoimmune Diabetes and Poor Glycaemic Control among Adults in Madagascar: A Brief Report from a Humanitarian Health Campaign in Ambanja |
| title_sort | high prevalence of autoimmune diabetes and poor glycaemic control among adults in madagascar a brief report from a humanitarian health campaign in ambanja |
| url | http://dx.doi.org/10.1155/2017/3860674 |
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