Simulation Modeling of a Pharmaceutical Tablet Manufacturing Process via Wet Granulation
The pharmaceutical tablet manufacturing process (PTMP) via wet granulation holds a critical position in pharmaceutical industry. The interest in integrating mechanistic process modeling into the pharmaceutical development has been increased because simulation model is a prerequisite for process desi...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Complexity |
| Online Access: | http://dx.doi.org/10.1155/2019/3659309 |
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| author | Zhengsong Wang Zhen Pan Dakuo He Jiahui Shi Shouxin Sun Yue Hou |
| author_facet | Zhengsong Wang Zhen Pan Dakuo He Jiahui Shi Shouxin Sun Yue Hou |
| author_sort | Zhengsong Wang |
| collection | DOAJ |
| description | The pharmaceutical tablet manufacturing process (PTMP) via wet granulation holds a critical position in pharmaceutical industry. The interest in integrating mechanistic process modeling into the pharmaceutical development has been increased because simulation model is a prerequisite for process design, analysis, control, and optimization. So the simulation modeling for PTMP via wet granulation is very necessary and significant. This study aims at proposing a simulation modeling framework for PTMP via spray fluidized bed granulation (SFBG), which is one of the most widely used wet granulation techniques in pharmaceutical industry. For SFBG, a simulation model that simultaneously involves the influences of operating variables and material attributes on average particle size (APS) is firstly developed, and then a drying model to determine the particle moisture content is introduced to be coupled with the established model predicting APS. For PTMP, considering the important effect of porosity on tablet qualities, a model describing the changes in tablet porosity is developed based on a promoted form of the Heckel equation, and then several recognized models that are all related to porosity are introduced or constructed to calculate important tablet quality indexes. The feasibility and effectiveness of the developed simulation models are validated by performing a computational experimental study to explore the scientific understanding of process and process quality control. |
| format | Article |
| id | doaj-art-060afb91bbe247e0a7e66a3ee79fac02 |
| institution | Kabale University |
| issn | 1076-2787 1099-0526 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Complexity |
| spelling | doaj-art-060afb91bbe247e0a7e66a3ee79fac022025-02-03T06:00:37ZengWileyComplexity1076-27871099-05262019-01-01201910.1155/2019/36593093659309Simulation Modeling of a Pharmaceutical Tablet Manufacturing Process via Wet GranulationZhengsong Wang0Zhen Pan1Dakuo He2Jiahui Shi3Shouxin Sun4Yue Hou5College of Information Science and Engineering, Northeastern University, Shenyang 110004, Liaoning, ChinaCollege of Information Science and Engineering, Northeastern University, Shenyang 110004, Liaoning, ChinaCollege of Information Science and Engineering, Northeastern University, Shenyang 110004, Liaoning, ChinaCollege of Information Science and Engineering, Northeastern University, Shenyang 110004, Liaoning, ChinaH3C Technologies Co., Limited, Beijing 100102, ChinaCollege of Life and Health Sciences, Northeastern University, Shenyang 110169, ChinaThe pharmaceutical tablet manufacturing process (PTMP) via wet granulation holds a critical position in pharmaceutical industry. The interest in integrating mechanistic process modeling into the pharmaceutical development has been increased because simulation model is a prerequisite for process design, analysis, control, and optimization. So the simulation modeling for PTMP via wet granulation is very necessary and significant. This study aims at proposing a simulation modeling framework for PTMP via spray fluidized bed granulation (SFBG), which is one of the most widely used wet granulation techniques in pharmaceutical industry. For SFBG, a simulation model that simultaneously involves the influences of operating variables and material attributes on average particle size (APS) is firstly developed, and then a drying model to determine the particle moisture content is introduced to be coupled with the established model predicting APS. For PTMP, considering the important effect of porosity on tablet qualities, a model describing the changes in tablet porosity is developed based on a promoted form of the Heckel equation, and then several recognized models that are all related to porosity are introduced or constructed to calculate important tablet quality indexes. The feasibility and effectiveness of the developed simulation models are validated by performing a computational experimental study to explore the scientific understanding of process and process quality control.http://dx.doi.org/10.1155/2019/3659309 |
| spellingShingle | Zhengsong Wang Zhen Pan Dakuo He Jiahui Shi Shouxin Sun Yue Hou Simulation Modeling of a Pharmaceutical Tablet Manufacturing Process via Wet Granulation Complexity |
| title | Simulation Modeling of a Pharmaceutical Tablet Manufacturing Process via Wet Granulation |
| title_full | Simulation Modeling of a Pharmaceutical Tablet Manufacturing Process via Wet Granulation |
| title_fullStr | Simulation Modeling of a Pharmaceutical Tablet Manufacturing Process via Wet Granulation |
| title_full_unstemmed | Simulation Modeling of a Pharmaceutical Tablet Manufacturing Process via Wet Granulation |
| title_short | Simulation Modeling of a Pharmaceutical Tablet Manufacturing Process via Wet Granulation |
| title_sort | simulation modeling of a pharmaceutical tablet manufacturing process via wet granulation |
| url | http://dx.doi.org/10.1155/2019/3659309 |
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