Methylation of the telomerase gene promoter region in umbilical cord blood of patients with gestational diabetes mellitus is associated with decreased telomerase expression levels and shortened telomere length

Methylation of the telomerase gene promoter region in umbilical cord blood of patients with gestational diabetes mellitus is associated with decreased telomerase expression levels and shortened telomere length

ObjectiveThis study speculates that gestational diabetes mellitus (GDM) may reduce fetal telomere length (TL),which may be related to modification of methylation in the promoter region of the telomerase (TE) gene promoter region.MethodsIn this study, umbilical cord blood samples from patients with a...

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Bibliographic Details
Main Authors: Shuhua Liu, Liping Xu, Yan Cheng, Dehong Liu, Bin Zhang, Xianxia Chen, Mingming Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Endocrinology
Subjects:
gestational diabetes mellitus
telomere length
telomerase
TERT
TERC
methylation
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1502329/full
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https://www.frontiersin.org/articles/10.3389/fendo.2025.1502329/full

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