Physiological serum uric acid concentrations correlate with arterial stiffness in a sex-dependent manner

Physiological serum uric acid concentrations correlate with arterial stiffness in a sex-dependent manner

Abstract Background In humans, uric acid is a product of purine metabolism that impacts the vascular system. In addition to effects on arterial vascular tone, associations between serum uric acid concentrations—even in the physiological range—and arterial hypertension and vascular-mediated end-organ...

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Main Authors: Oliver Thews, Thomas Schmid, Alexander Kluttig, Andreas Wienke, Melanie Zinkhan, Wolfgang Ahrens, Till Bärnighausen, Hermann Brenner, Stefanie Castell, Berit Lange, Wolfgang Lieb, Karin Halina Greiser, Marcus Dörr, Lilian Krist, Stefan N. Willich, Volker Harth, Nadia Obi, Michael Leitzmann, Annette Peters, Börge Schmidt, Matthias B. Schulze, Henry Völzke, Matthias Nauck, Stephanie Zylla, Anke Hannemann, Tobias Pischon, Ilais Moreno Velásquez, Matthias Girndt, Claudia Grossmann, Michael Gekle
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Medicine
Subjects:
Urate
Vascular stiffness
Vascular damage
Pulse wave velocity
Hyperuricemia
Female health
Online Access:https://doi.org/10.1186/s12916-025-04195-8
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https://doi.org/10.1186/s12916-025-04195-8

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